| Title of the poster |
Authors |
Postersession I - Sunday, September 15th, 2013
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| Progress in 3Rs' research - EU FP6 and FP7 projects |
| The COSMOS Project - Developing Integrated Computational Approaches to Predict Repeated Dose Toxicity |
Judith Madden, Andrea Richarz, Daniel Neagu, Chihae Yang, Elena Fioravanzo, Alexandre Pery, Andrew Worth, Michael Berthold, Mark Cronin |
| 3Rs go 3D |
| Monitoring of multilayer development of human 3D cornea constructs by trans-epithelial impedance measurement |
Joachim Wiest, Anja Steininger, Toni Lindl |
| 3D Organotypic cultures of liver cells for metabolism and toxicity testing |
Fozia Noor |
| A human liver 3D cell model for substance testing |
Christine Schäfer, Klaus R. Schröder, Mohammad Reza Lornejad-Schäfer |
| Basic and biomedical research |
| Evaluation of two new recombinant Factor C based assays as alternatives for Limulus blood based endotoxin detection methods |
Johannes Reich, Wolfgang Mutter, Holger Grallert |
| Comparison of standard and fetal-calf-serum-free cell culture media by impedance measurement |
Joachim Wiest, Roman Kolar, Irmela Ruhdel |
| Topical application of cationic membrane-active peptides: enzymatic degradation by human skin ex vivo and the effect on skin penetration |
Günther Weindl, Nhung Do, Mario Salwiczek, Beate Koksch, Monika Schaefer-Korting |
| A New Organotypic 3-D Human Small Intestinal Tissue Model Reconstructed from Primary Human Cells |
Seyoum Ayehunie, Zachary Stevens, Timothy Landry, Alex Armento, Mitchell Klausner, Patrick Hayden |
| Human on a chip |
| A novel, flexible method for assessing barrier tissue integrity |
Roisin Owens |
| “Skin on a Chip” - Perfused long term culture of skin tissue |
Ilka Wagner, Beren Atac, Gerd Lindner, Frank Sonntag, Roland Lauster, Uwe Marx |
| Dynamic culture of human liver equivalents inside a micro-bioreactor for long-term substance testing |
Tobias Hasenberg, Eva-Maria Materne, Caroline Frädrich, Ute Süßbier, Reyk Horland, Silke Hoffmann, Sven Brincker, Alexandra Lorenz, Mathias Busek, Frank Sonntag, Roland Lauster, Uwe Marx |
| Disease Models |
| Next Generation Sequencing (NGS) approaches to detect fixed point mutations in human airway epithelia |
Klaus Sommer, Elke Bradt, Samuel Constant, Damien Breheny, Klaus R. Schröder |
| Investigation into the inflammatory response of the H292 lung epithelial model to cigarette smoke particulate generated using different smoking regimes and reduced toxicant prototypes |
Sarah Corke, Linsey Haswell, Katherine Hewitt Hewitt, Geoff Foss-Smith, David Azzopardi, Gary Phillips |
| In Vitro Non-Melanoma Skin Cancer Model for Toxicity Testing and Pre-Clinical Drug Evaluation |
Christian Zoschke, Nesrin Alnasif, Emanuel Fleige, Rainer Haag, Hans F Merk, Günther Weindl, Sarah Küchler, Monika Schaefer-Korting |
| Novel 3-D reconstructed human tissues model of psoriatic skin |
Seyoum Ayehunie, C. Hedin, Timothy Landry, M. Spratt, M Clark, T. Kupper, Mitchell Klausner |
| TISSUE ENGINEERED IN VITRO HUMAN AIRWAY MODELS (EPIAIRWAY) OF ASTHMA AND COPD |
Patrick Hayden, R. Jackson, J Bolmarcich, Mitchell Klausner |
| Human epidermis reconstructed from UVB-irradiated keratinocytes mimics premature ageing in human skin |
Lilian Julia Löwenau, Suvara Wattanapitayakul, Johanna M. Brandner, Günther Weindl, Monika Schaefer-Korting |
| Alterations of canalicular and basolateral transporters by cyclosporin A in human HepaRG® cells |
Ahmad SHARANEK, Pamela BACHOUR-EL AZZI, Christiane Guguen-Guillouzo, Andre GUILLOUZO |
| GCCP - Good cell culture practice |
| Human Platelet Lysates Successfully Replace Fetal Bovine Serum in Adipose-derived Adult Stem Cell Culture |
Caroline Rauch, Elisabeth Feifel, Gerhard Gstraunthaler |
| Human Platelet Lysates Promote the Differentiation Potential of Adipose-derived Adult Stem Cell Cultures |
Caroline Rauch, Elisabeth Feifel, Angelika Flörl, Kristian Pfaller, Gerhard Gstraunthaler |
| Importance of reproducibility demonstration of the bio-engineered tissue models used for in vitro toxicity testing purposes |
Silvia Letasiova, Helena Kandarova, Michael Bachelor, Paul Kearney, Mitchell Klausner |
| Drugs, vaccines and medical devices |
| A 3R TEST OF BIOCOMPATIBILITY OF A NEW INTENSIVE PATCH BY USING THE RECONSTITUTED THREE-DIMEMSIONAL HUMAN SKIN MODEL EPISKIN-SM™ (SkinEthic) TO REPLACE ANIMAL USE |
Conrad Julius |
| Construction of an Impedance monitoring system for cell seeding and drug screening in a 3D cell culture model |
Christine Schäfer, Wolfgang Hilber, Klaus R. Schröder, Berhard Jakoby, Mohammad Reza Lornejad-Schäfer |
| Confocal µ-Raman spectroscopy of living cells |
Susanne Kimeswenger, Krisztina-Andrea Vincze-Minya, Klaus R. Schröder, Sabine Hild, Mohammad Reza Lornejad-Schäfer |
| In Vitro Phototoxicity Screening Assay for Systemically Administered Pharmaceuticals Using a Reconstructed Skin Model EpiDerm |
Yulia Kaluzhny, M. W. Kinuthia, Patrick Hayden, Laurence d’Argembeau-Thornton, Helena Kandarova, Mitchell Klausner |
| Free Communications |
| Non-testing strategies - a tiered approach |
R. Arno Wess |
| In vitro toxicity testing: influence of different cell lines and endpoints |
Pavel Kosina, Adéla Galandáková, Sylva Snášelová, Jitka Ulrichová |
| Ologen® Collagen Matrix: a new dermal scaffold for skin tissue engineering |
Suzan Commandeur, Sarah Sparks, Lisanne van Zijl, Marion Rietveld, Horng Ji Lai, Chien C. Lin, Abdoel El Ghalbzouri |
| Alternative methods in education: what do students think? |
Francesca Caloni, Alexis Theodoridis, Vangelis Kehagias, Cristina Cortinovis, Fabiola Pizzo, Magdalini Sachana |
| THE ANTIPROLIFERATIVE, PROAPOPTOTOTIC AND ANTITUMOR ACTIVITY OF HuIFN-α AGAINST CaCo-2 CELLS CAN BE ENHACED WITH 10% PBS HOLOCENE GRAIN WASH OUT |
FILIPIC BRATKO, Gradisnik Lidija, Mazija Hrvoje, Miko Slobodan, EUGEN ŠOOŠ, SRECKO KOREN |
| Improving cadaveric models for surgery teaching and training |
Maria Claudia Inglez de Souza, Antonio Augusto Ribeiro, Julia Maria Matera |
| Animal Testing and Transparency – a Contradiction in Terms? Presenting a Project to Promote both, Transparency of Animal Testing and the Social Dialogue between Proponents and Opponents |
Vera Marashi, Norbert Alzmann, Herwig Grimm |
| HuIFN-αN3 inducing capacity of the Newcastle disease virus (NDV) ZG1999HDS |
FILIPIC BRATKO, Adriana Pereyra, Mazija Hrvoje, EUGEN ŠOOŠ, JANA POTOKAR, SRECKO KOREN |
| The Lush Prize – Supporting Animal Free Testing |
K. Brown and R. Harrison |
| InterNICHE outreach and replacement of animal experiments in education in Uzbekistan and Kyrgyzstan |
Nick Jukes and Dmitry Leporsky |
| Humane education and ethical science: Campaigning for replacement in Iran |
Ramak Roshanaie and Nick Jukes |
| |
|
Postersession ESNATS, Monday, September 16th, 2013
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| ESNATS - embryonic stem cells |
| Development of a microfluidic biochip for chronic monitoring of 3D neural tissues derived from human Embryonic Stem Cells |
Luc Stoppini, Antonin Sandoz, Igor Charvet |
| Epigenetically-conserved biomarkers of an undifferentiated human embryonic stem cell phenotype |
Steve Pells, Eirini Koutsouraki, Sofia Morfopoulou, Sara Valencia-Cadavid, Andy Malinowski, Rachel Riddoch, Simon Tomlinson, Ravi Kalathur, Matthias Futschik, Paul De Sousa |
| Elucidation of perturbed pathways by using stem cell derived neural progenitors |
Dimitra Zagoura, Francesca Pistollato, Jochem Louisse, Silvia Colleoni, Giovanna Lazzari, Agapios Sachinidis, Susanne Bremer |
| Testing neurodevelopmental toxicity on differentiating human embryonic stem cells |
Anne-Catherine FEUTZ, Christian DE GEYTER |
| Development of a neural teratogenicity test: comparative microarray analysis of two different hESCs lines following exposure to valproic acid |
Silvia Colleoni, Cesare Galli, John Antony Gaspar, Kesavan Meganathan, Smita Jagtap, Jürgen Hescheler, Susanne Bremer, Agapios Sachinidis, Giovanna Lazzari |
| Qualification of neural differentiation protocols and points to consider when transferring standardized protocols between laboratories. |
Orla O'Shea, Lyn Healy, Glyn Stacey |
| The role of dioxygenases in human embryonic stem cells |
Eirini Koutsouraki, Steve Pells, Paul De Sousa |
| Defining compound subcytotoxic effects on epigenetic determinants of human embryonic stem cell renewal and lineage commitment |
Eirini Koutsouraki, Paul De Sousa |
| Human Embryonic Stem Cells Differentiation Reveals Toxicity Signatures for HDAC inhibitors and Mercuric Toxicants |
Kesavan Meganathan, Smita Jagtap, Sureshkumar Perumal Srinivasan, Vaibhav Shindev, Vilas Wagh, Jürgen Hescheler, Agapios Sachinidis |
| |
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Postersession II, Tuesday, September 17th, 2013
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| Directive 2010/63/EU and implementation into national legislation |
| The harm:benefit assessment under the new Directive 2010/63- will any projects be rejected? |
Katy Taylor |
| „Taking Ethical Considerations Into Account? Methods to Carry Out the Harm-Benefit Analysis According to the EU Directive 2010/63/EU“. Summary of a Symposium at the Messerli Research Institute |
Vera Marashi, Norbert Alzmann, Herwig Grimm |
| Regulatory toxicity testing & 2013 marketing ban for cosmetics |
| Review of REACH from an animal protection perspective |
Katy Taylor |
| How many animals have been really used for REACH purposes: appraisal after the second deadline |
Costanza Rovida |
| REACH – Who is responsible for ensuring that animal testing is conducted only as a last resort? |
Gilly Stoddart |
| The way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance? |
Tatyana Doktorova, Gamze Ates, CHRISTOPHE CHESNE, Tamara Vanhaecke, Vera Rogiers |
| Acute toxicity of alcohols determined by alternative methods |
Marian Rucki, Kristina Kejlova, Dagmar Jirova |
| Analysis of the Validated Epiderm Skin Corrosion Test (EpiDerm SCT) and a Prediction Model for Sub-Categorization According to the UN GHS and EU CLP. |
Helena Kandarova, Silvia Letasiova, Tatiana Milasova, Patrick Hayden, Mitchell Klausner |
| Specific toxicological endpoints |
| Are structural analogs to bisphenol A a safe alternative? |
Anne Marie Vinggaard |
| A ‘low toxicity profile’ can waive the 90-day repeated dose test for REACH |
Katy Taylor |
| Dialogue with EFSA to avoid useless animal testing in the area of genotoxicity |
Costanza Rovida, Mario Aquino |
| Development and characterization of a bioengineered conjunctiva model on the basis of immortalized cells |
Michaela Zorn-Kruppa, Melinda Bartok, Detlef Gabel, Maria Engelke, Kerstin Reisinger, Karolina Daton, Karsten Mewes, Johanna M. Brandner |
| In silico models for dermal absorption from complex formulations |
Katharina Guth, Jim Riviere, Jim Brooks, Monika Schaefer-Korting, Martina Dammann, Eric Fabian, Bennard van Ravenzwaay, Robert LANDSIEDEL |
| Alternative Method in practice: postvalidation experience of the skin sensitization in vitro test strategy |
Susanne N Kolle, Annette Mehling, Naveed Honarvar, Wera Teubner, Bennard van Ravenzwaay, Robert LANDSIEDEL |
| Neurotoxicity in vitro: assessment of the predictivity of neuronal networks coped to microelectrode arrays for identification of neurotoxicants |
Tzutzuy Ramirez Hernandez, Timo Weisschu, Hans-Albrecht Huener, Bennard van Ravenzwaay, Robert LANDSIEDEL |
| Screening of a large group of medical substances and environmental pollutants in a neural crest stem-cell based functional migration assay |
Giorgia Pallocca, Bastian Zimmer, Nadine Dreser, Sunniva Foerster, Nina Balmer, Stephanie Julien, Karl-Heinz Krause, Sieto Bosgra, Marcel Leist |
| Using the Slug Mucosal Irritation assay to predict discomfort caused by ophthalmic formulations |
Joke Lenoir, Ilse Claerhout, Philippe Kestelyn, Jean-Paul Remon, Els Adriaens |
| Study on development for the alternative methods for photo-toxicity and photo-genotoxicity tests using mouse keratinocytes and human 3D skin model |
So Young Kim, Yong Kyoung Lee, Mi Hyang Nam, Chea Hyung Lim, Jun Young Yang, Il Young Ahn, Ki Hwan Choi |
| Results of a (pre)validation study of the Hen’s Egg Test for Micronucleus-Induction (HET-MN) |
Katrin Maul, Dagmar Fieblinger, Andreas Heppenheimer, Juergen Kreutz, Andreas Luch, Ralph Pirow, Albrecht Poth, Kerstin Reisinger, Pamela Strauch, Thorsten Wolf |
| Characterization of lymphoblastoid cell lines as a novel in vitro test system to predict immunotoxicity of xenobiotics |
Tijana Markovic, Martina Gobec, David Gurwitz, Irena Mlinaric-Rascan |
| Evaluation of the sub-classification of dermal corrosives in vitro using the epiCS® (CellSystems) reconstructed human skin model |
Dirk Weisensee, Oliver Engelking, Tanja Klein, Daniel Fuchs, Horst Fuchs |
| The human placenta in toxicology |
Udo Markert, Andre Schmidt, Claudia Göhner, Jana Pastuschek, Maja Weber |
| Neurospheres as a predictive 3D in vitro model for DNT testing and pathway investigation in a species-specific context. |
Ellen Fritsche, Kathrin Gassmann, Susanne Giersiefer, Janette Schuwald, Jenny Baumann |
| The DNT-EST: a predictive embryonic stem cell test for developmental neurotoxicity testing in vitro. |
Andrea Seiler, Katrin Hayess, Christian Riebeling, Ralph Pirow, Matthias Steinfath, Dana Sittner, Birgitta Slawik, Konrad Gulich, Andreas Luch |
| Optimization of the EpiOcular Eye Irritation Test for Hazard Identification and Labelling of Chemicals in Response to the Requirements of the EU Cosmetic Directive and REACH Legislation |
Yulia Kaluzhny, Helena Kandarova, Laurence d’Argembeau-Thornton, J. De Luca, Patrick Hayden, Amy Hunter, Thoa Truong, Mitchell Klausner |
| Improving genotoxicity testing to avoid or minimize the number of animals: an EURL ECVAM proposal |
Federica Madia, Raffaella Corvi, Andrew Worth and Maurice Whelan |
| Nanotoxicology |
| Studies on the mode of action of Multi-walled Carbon Nanotubes onto human bronchial epithelial cells |
Dorothee Walter, Monika Niehof, Anja Hackbarth, Tanja Hansen |
| Molecular Recognition Force Microscopy/Spectroscopy |
Peter Hinterdorfer, Lilia Chtcheglova |
| Genotoxicity of nanosized TiO2 particles in human reconstructed full thickness skin models |
Dagmar Fieblinger |
| Genotoxicity of nanosized Titanium dioxide particles in 16HBE14o- cells |
Mario Gotz |
| Ecotoxicology |
| In vitro toxicology of air samples: Breathe or not to breathe? |
Anita Érseková, Jana Klánová, John Giesy, Jiři Novak |
| Ethical & legal issues |
| Use of Animals and Alternatives in Military Medical Training by NATO Nations |
Justin Goodman |
| Toxicology in the 21st century |
| Verification of Systems Biology Research in the Age of Collaborative- Competition |
Marja Talikka |
| Moving forward: a new paradigm for drug discovery. |
Meg Lewis, J Malcolm Wilkinson |
| Human 3D corneal models for a detailed quantification of the initial depth of injury as an indicator for cellular damage in the human eye |
Melinda Bartok, Detlef Gabel, Maria Engelke, Michaela Zorn-Kruppa, Johanna M. Brandner, Kerstin Reisinger, Karolina Daton, Karsten Mewes |
| Coupling of the BALB/c-3T3 cell transformation assay to a metabolic activation system and to the soft agar colony formation assay: determination of two endpoints in a single in vitro test system |
Maria Daniela Brauneis, Pablo Steinberg |
| What is relevant? |
Martin Paparella, Mardas Daneshian, Romana Hornek-Gausterer, Maximilian Kinzl, Ilse Mauritz, Simone Mühlegger |
| Using 21st Century toxicology to model disease risk |
Karina McQuillan |
|
From Biotech to FDA: Validation of in Vitro Methods of Prediction of Human Toxicity
|
Robert A Coleman |
