19th European Congress on Alternatives to Animal Testing, September 20-23 2015, University of Linz, Austria

Program by days

(v. 17.09.2015)

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Sunday, 20 September 2015
Opening 13:00-13:45
HALL 1    
13:00-13:10   Welcome addresses
13:10-13:15   Signing of the co-operation agreement between EUSAAT and JSAAE - the Japanese Society for Alternatives to Animal Experiments
13:15-13:45   Opening lecture: Directive 2010/63/EU - achievements and challenges
Susanna Louhimies, BE-Brussels
Scientific sessions 13:45-15:15
18.1: 3Rs in Academia & Education I
Chairs: Ellen Fritsche, DE-Düsseldorf & Monika Schäfer-Korting, DE-Berlin
HALL 3
   
 13:45-14:03   The Berlin-Brandenburg Research Platform BB3R and integrated graduate school
Monika Schäfer-Korting
, DE-Berlin
 14:03-14:21   CERST-NRW: a German state government of North Rhine Westphalia-funded initiative for the development of alternative methods to animal testing
Ellen Fritsche
, DE-Düsseldorf
14:21-14:39   Teaching alternative methods in toxicology in veterinary science
Francesca Caloni
, IT-Milano
14:39-14:57   Romanian Center for Alternative Test Methods (ROCAM) – a newly established 3Rs Center to promote and support the alternative methods field in Romania
Lucian Farcal
, RO-Cluj-Napoca
14:57-15:15   CAAT-Europe and knowledge exchange on the progress of the 3Rs and research methods
Marcel Leist
, DE-Konstanz
9.1: Skin Sensitization I
Chairs: Robert Landsiedel, DE-Ludwigshafen & Joao Barroso, IT-Ispra
HALL 1
   
13:45-14:15   Outlook on currently available non-animal test methods for skin sensitization testing
Daniel Urbisch
, DE-Ludwigshafen
14:15-14:45   Reconstituted Human Epidermis Models and IL-18 Levels for Identification and Potency Ranking of Skin Sensitizers: Identification of Critical Steps and Harmonization of Existing Protocols for the Purpose of Validation
Erwin Roggen
, DK-Bagsvaerd
shifted to Monday, session 10.2.
14:45-15:15   Evaluating non-animal methods for identifying skin sensitisation hazards: A Bayesian value of information analysis
Maria Leontaridou, DE-Ludwigshafen
15:15-16:00   Coffee break and posters
Scientific sessions 16:00-17:30  
12.1: Disease Models I: CRISPR/Cas
Chairs: Horst Spielmann, DE-Berlin & Malte Spielmann, DE-Berlin    
HALL 1
   
16:00-16:10   Scientific and animal welfare issues surrounding the new CRISPR/Cas-9 approach to produce transgenic animals and advanced in vitro disease models
Horst Spielmann, DE-Berlin 
16:10-16:40   CRISPR/Cas-induced structural variants
Malte Spielmann, DE-Berlin
16:40-17:05   Paving the way to a novel analysis platform to study human diseases
Saniye Sprenger, DE-Berlin 
17:05-17:30   Modeling the air-blood-barrier in state of disease – challenges and perspectives
Marius Hittinger, DE-Saarbrücken 
3.1: 3D Models I
Chairs: Ellen Fritsche, DE-Düsseldorf & Tzutzuy Ramirez, DE-Ludwigshafen    
HALL 3    
16:00-16:18   Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events
Ellen Fritsche, DE-Düsseldorf 
16:18-16:36   Stem-cell based in vitro models to study human CNS pathophysiology
Zeynab Nayernia, CH-Geneva 
16:36-16:54   The use of the 'Neurosphere-Assay’ to study specific disturbances on FGF-2 function during neurodevelopment
Marta Barenys, DE-Düsseldorf 
16:54-17:12   Assessment of the predictivity of neuronal networks coped to microelectrode arrays for identification of neurotoxicants
Tzutzuy Ramirez, DE-Ludwigshafen
17:12-17:30   Advances in in vitro testing: the route to replace animal testing
Stella Homer, UK-Rotherham
18:00-22:00   Welcome reception (at the congress venue)
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Monday, 21 September 2015 
Scientific sessions 09:00-10:30   
1.1: Multi-Organ-Chips I
Chairs: Uwe Marx, DE-Berlin & Dmitry Sakharov, RU-Moscow  
HALL 1
   
09:00-09:30   Six organ chip for substance toxicity testing using Homunculus platform
Dmitry Sakharov, RU-Moscow 
09:30-10:00   Pro-drug activation in a dynamic microfluidic systems interconnecting liver and tumor micro-tissues"
Jens Kelm, CH-Schlieren 
10:00-10:30   Mimicking the cyclic mechanical stress of the lung parenchyma in a breathing lung-on-chip
Janick Stucki, CH-Bern 
2: Stem Cells
Chairs: James Adjaye, DE-Düsseldorf & Jürgen Hescheler, DE-Köln   
HALL 3    
09:00-09:18   Geometrically confined cell differentiation and migration model for human teratogen detection
Jiangwa Xing, SG-Singapore 
09:18-09:36   Quantitative data on toxicant classification derived from transcriptomics studies of stem cell development
Marcel Leist, DE-Konstanz 
09:36-09:54   Vascular-like network enhances structural and functional maturation of human pluripotent stem sell derived cardiomyocytes in cardiovascular construct
Hanna Vuorenpää, FI-Tampere 
09:54-10:12   Human induced pluripotent stem cells as tools for studying the etiology of Non Alcoholic Fatty Liver Disease
James Adjaye, DE-Düsseldorf 
10:12-10:30   Differentiated human skin-derived stem cells as a novel cell source for in vitro screening of drug-induced liver injury (DILI)
Vera Rogiers, BE-Brussels 
10.2: Efficacy & Safety Testing II - Biologicals and Vaccines
Chairs: Emina Wild
, DE-Langen & Sebastian Hoffmann, DE-Paderborn
HALL 2
   
09:00-09:18   In vitro assays for the potency determination of botulinum neurotoxin serotypes A and B
Emina Wild, DE-Langen 
09:18-09:36   Avian encephalomyelitis live vaccines - alternative methods for batch virus titration
Lena Rimpel, DE-Langen 
09:36-09:54   Reconstituted Human Epidermis Models and IL-18 Levels for Identification and Potency Ranking of Skin Sensitizers: Identification of Critical Steps and Harmonization of Existing Protocols for the Purpose of Validation
Erwin Roggen
, DK-Bagsvaerd
09:54-10:12   Pro- and pre-hapten mechanisms in skin sensitization
David Roberts
, UK-Liverpool
10:12-10:30   LLNA variability: an essential ingredient for a comprehensive assessment of non-animal skin sensitisation test methods and strategies
Sebastian Hoffmann
, DE-Paderborn
10:30-11:00   Coffee break and posters 
Scientific sessions 11:00-12:30 
5.2: QSAR & Read Across II - QSAR
Chairs: Karel de Raat, FI-Helsinki & Matthias Herzler, DE-Berlin 
HALL 3    
11:00-11:18   Use of (Q)SARs under REACH - perspective of a regulator
Matthias Herzler, DE-Berlin 
11:18-11:36   Application of in silico methods for predictions of different toxicological endpoints
Malgorzata Drwal, DE-Berlin 
11:36-11:54   QsarDB: solution strategy for efficient use of QSAR models
Uko Maran, EE-Tartu 
11:54-12:12   The Future of the QSAR Toolbox: moving to less uncertainty in predictive toxicology
Romualdo Benigni, IT-Roma 
12:12-12:30   Weighted gene co-expression network analysis to characterize drug induced cardiotoxicity
Jufeng Wang
, CN-Beijing 
11: Nano-Toxicology
Chairs: Natalie Burden, UK-London & Robert Landsiedel, DE-Ludwigshafen
HALL 1
   
11:00-11:15   Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long term opportunities?
Natalie Burden, UK-London 
11:15-11:30   NanoSafety research and its challenges!
Peter Wick, CH-St. Gallen
11:30-11:45   Cytotoxic and immunological effects of engineered nanomaterials
Marika Mannerstrom, FI-Tampere
11:45-11:55   Adressing inflammatory parameters of the intestinal mucosa: From the mouse to the test tube
Benno Weigmann, DE-Erlangen 
11:55-12:05   An advanced 3D human epithelial airway model to study the biokinetics of aerosolized biomedical nanoparticles after repeated exposures
Savvina Chortarea, CH-Fribourg 
12:05-12:15   Towards the prediction of nanoparticle-induced inhalation toxicity: Evaluation of an in vitro macrophage assay
Martin Wiemann, DE-Münster
12:15-12:30   A decision-making framework for the grouping and testing of nanomaterials
Robert Landsiedel, DE-Ludwigshafen 
12.2: Disease Models II: hiPSC
Chairs: Manfred Liebsch, DE-Königs Wusterhausen & Justine Miller, US-Rensselaer NY
HALL 2
   
11:00-11:20   Reconstructed human skin pioneers the implementation of diversity into preclinical testing in vitro
Monika Schäfer-Korting
, DE-Berlin 
11:20-11:40   Human stem-cell based functional neuronal in vitro disease models
Susanna Narkilahti, FI-Tampere 
11:40-12:00   Alzheimer's disease research in the 21st century: the shift towards a new paradigm
Francesca Pistollato, US-Washington DC 
12:00-12:20   In vitro hiPSC-based modeling of late-onset disease using progerin-induced aging
Justine Miller, US-Rensselaer NY
12:30-13:30   Business lunch (to be served at the congress venue) and posters
Scientific sessions 13:30-15:00
4: International Progress in 3Rs' Research & Global Cooperation on Implementing the 3Rs
Chairs: Hajime Kojima, JP-Tokyo & Troy Seidle, CND-Toronto
HALL 2
   
13:30-13:48   Beyond Europe: Accelerating regulatory uptake and use of 3R best practices globally
Troy Seidle, CA-Toronto 
13:48-14:06   EPAA - 10 years of progress and more to do
Renate Weissenhorn, BE-Brussels 
14:06-14:24   The Asian Congress on Alternatives and Animal Use in the Life Sciences 2016
Hajime Kojima, JP-Tokyo 
14:24-14:42   Transatlantic collaboration of Cosmetics Europe with NICEATM/ILS to assess and develop strategy for skin sensitisation safety assessment without animal testing
Sebastian Hoffmann, DE-Paderborn 
14:42-15:00   Decision Algorithm for 3R (Refine, Reduce, Replace) Programs - a case study in vaccines
Iwona Wilk-Zasadna, CH-Basel 
6: Risk Assessment Based on the AOP Concept
Chairs: Ellen Fritsche, DE-Duesseldorf & Anna Bal-Price, I-Ispra
HALL 3
   
13:30-13:48   MIEs – the gateways to pathway prediction
Paul Russell, UK-Shambrook 
13:48-14:06   Integration of the epidemiological data with the experimental toxicity studies on pesticides; use of the AOP framework for the definition of biological plausibility
Andrea Terron, IT-Parma 
14:06-14:24   Characterization of the effects of epigallocatechin gallate (EGCG) exposure during neurodevelopment within the AOP concept
Marta Barenys, DE-Düsseldorf 
14:24-14:42   Applying Adverse Outcome Pathways to support Integrated Approaches to Testing and Assessment (IATA)
João Barroso, IT-Ispra 
14:42-15:00   Adverse Outcome Pathway Knowledge Base: A crowdsourcing tool to add value to existing information on Alternative Methods results
Clemens Wittwehr, IT-Ispra 
14: EU Directive 2010/63/EU on the Protection of Animals Used for Scientific Purposes
Chairs: Herman Koeter, NL-Den Haag & Susanna Louhimies, BE-Brussels
HALL 1    
13:30-13:55   Directive 2010/63/EU: five years after its adoption
Herman Koeter, NL-Den Haag 
13:55-14:15   Non-technical summaries - a review of EU member states efforts so far
Katy Taylor
, UK-London
14:15-14:30   Different concepts of committees in EU member states, to support the competent authorities performing the project evaluation according to Directive 2010/63/EU
Norbert Alzmann, AT-Vienna 
14:30-14:45   The Role of the National Committee in Germany - Severity Assessment of Genetically Altered Animals
Bettina Bert
, DE-Berlin
14:45-15:00   Legal issues in the work of the German National Committee: an overview
Justyna Chmielewska, DE-Berlin
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15:00-15:30   Coffee break and posters  
Scientific sessions 15:30-17:00      
1.2: Multi-Organ-Chips II
Chairs: Dmitry Sakharov, RU-Moscow & Uwe Marx, DE-Berlin 
HALL 1    
15:30-16:00   Microfluidic in vitro platform for parallel human multi-tissue interaction studies
Jin-Young Kim, CH-Zurich 
16:00-16:30   Emulating the human vasculature in a multi-organ-chip platform
Tobias Hasenberg, DE-Berlin 
16:30-17:00   Cryopreserved human hepatocytes and IdMOC experimental system for the evaluation of human drug properties
Albert Li, US-Columbia MD 
15.1: Ethics & Legal Issues I
Chairs: Herwig Grimm, AT-Vienna & Emily McIvor, UK-Seaton
HALL 3
   
15:30-15:50   Pain for Profit. Can monetary reasons justify animal research ethically?
Herwig Grimm, AT-Vienna 
15:50-16:10   Evaluation of the scientific validity of animal experiments in Switzerland
Lucile Vogt, CH-Bern 
16:10-16:30   Implementing the 3Rs: turning words into action
Emily McIvor, UK-Seaton 
18.2: 3Rs in Academia & Education II
Chairs: Marcel Leist, DE-Konstanz & Candida Nastrucci, IT-Rome  
HALL 2
   
15:30-15:43   Reboot3R - Design Thinking Workshops for scientists to constructively find ways to apply 3Rs within their own career
Cecilia Hilmer, DE-Berlin 
15:43-15:56   Animal Research: critical, challenging & creative thinking about the 3Rs
Juliet Dukes, UK-Southwater 
15:56-16:09   A Course in Alternatives: focus on replacement and non-animal methods
Candida Nastrucci, IT-Rome 
16:09-16:22   Follow-up on 2013 EUSAAT’s Congress and its impact for Sri Lankan scientific community in 3Rs
Mangala Gunatilake, LK-Colombo
 
16:22-16:35   Improving animal welfare through competence: The EUPRIM-Net education and training programs
Valeska Marija Stephan, DE-Göttingen 
16:35-16:48   Refinement of welfare through application of a quantitative system for assessment of lifetime experience
Michael Dennis
, UK-Salisbury
16:48-17:01   Journal policies on animal use – current landscape and future directions
Nuno Henrique Franco, PT-Porto 
17:00-19:00   Poster session I with coffee - authors present
Survey of the posters with presence of the authors
19:00-20:30   Annual General Assembly of EUSAAT (members only)
Tuesday, 22 September 2015
Scientific sessions 09:00-10:30  
17.1: Replacement I
Chairs: Mardas Daneshian, DE-Konstanz & Candida Nastrucci, IT-Rome  
HALL 3
   
09:00-09:20

  Animals are not 'Materials and Methods': Why it is important to focus on Replacement
Candida Nastrucci, IT-Rome 
09:20-09:35

  Examination of human bone tissue regeneration using the chorioallantoic membrane (CAM): an ex vivo replacement model for animal research
Ines Moreno, UK-Southampton
09:35-09:55

  Strategies for combining skin and vasculature in a Multi-Organ-Chip Platform
Katharina Schimek, DE-Berlin 
09:55-10:10   Stem cell-derived human dorsal root ganglia-like cells to identify peripheral neurotoxicants
Lisa Hoelting, DE-Konstanz
10:10-10:30   Functional neurons from cancer cells: a novel in vitro model exhibits appropriate functional parameters
Susanna Alloisio, IT-Genoa 
10.1: Efficacy & Safety Testing I
Chairs: Tuula Heinonen, FI-Tampere & Anett Ullrich, DE-Schwerin
HALL 2
   
09:00-09:30   A relevant in vitro model for safety testing of chemicals and efficacy testing of pharmaceuticals
Tuula Heinonen, FI-Tampere 
09:30-09:45   Characterization of transporter activities in different cell types by using fluorescent substrates
Anett Ullrich, DE-Schwerin 
09:45-10:10   Development, optimization and standardization of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm
Helena Kandarova, SK-Bratislava 
10:10-10:30   HTS for screening of selective muscarinic cholinergic receptors antagonists
Valerii Tonkopii
, RU-St. Petersburg
15.2: Ethics & Legal Issues II
Chairs: Roman Kolar, DE-Neubiberg & Stefanie Schindler, CH-Zurich
HALL 1    
09:00-09:18   Update on 3Rs activities at the EU institutional level and beyond the borders
Francois Busquet, BE-Brussels 
09:18-09:36   40 years of Animalfree Research. Results and lessons learned from a quality assessment      
Stefanie Schindler
, CH-Zurich 
09:36-09:54   Non-animal Testing: It’s within REACH
Julia Baines
(replacing Gilly Stoddart), UK-Colchester  
09:54-10:12   REACH, the Cosmetics Regulation and upholding the animal testing ban
Julia Baines
, UK-Colchester 
 10:12-10:30   Harm-benefit analysis of animal experimentation: a qualitative study of ethics committee practice in six European countries
Anna Olsson, PT-Porto 
10:30-11:00   Coffee break and posters
Scientific sessions 11:00-12:30  
7: Repeated Dose Toxicity & Other Toxicological Endpoints
Chairs: Klaus-Rudolf Schröder, AT-Linz & Joachim Wiest, DE-Munich
HALL 1    
11:00-11:25   Towards the replacement of in vivo repeated dose systemic toxicity: Achievements of the SEURAT-1 research initiative
Tilmann Gocht, DE-Tübingen 
11:25-11:40   Metabolomics in vitro: a new approach for systemic toxicity – first applications for mode of action identification and chemical grouping
Tzutzuy Ramirez
, DE-Ludwigshafen
11:40-11:55   28-day microphysiological monitoring of human hepatocellular cells
Joachim Wiest, DE-Munich
11:55-12:05   Generation of the molecular basis for studying thyroid hormone disruption in neural progenitor cells of humans and rats
Susanne Giersiefer, DE-Düsseldorf
12:05-12:15   Quantitative analysis of cell migration in the wound healing scratched assay by Using Active Contour Model and Speeded Up Robust Features
Melika Farshad, IR-Shiraz
12:15-12:30   Failure and Success: in vitro ocular irritation test methods for agrochemical formulations the Bovine Cornea Opacity and Permeability Test and the EpiOcular™ Eye Irritation Test
Susanne Kolle, DE-Ludwigshafen
9.2: Skin Sensitization II
Chairs: Helena Kandarova
, SK-Bratislava &
Gavin Maxwell, UK-Shambrook
HALL 3
   
11:00-11:30   Towards the assessment of skin sensitization potency: Quantitative estimations by the Direct Peptide Reactivity Assay
Susanne Kolle, DE-Ludwigshafen
11:30-11:50   From pathways to people: Applying the skin sensitisation AOP to risk assessment
Gavin Maxwell
, UK-Shambrook
11:50-12:10   Functional characterization of reconstructed skin containing in vitro generated Langerhans cells
Günther Weindl, DE-Berlin
12:10-12:30   Evaluation of an in vitro human dermal sensitization test for use with medical device extracts
Jamin A. Sr. Willoughby, US-Kalamazoo MI
16.2: Refinement II
Chairs: Katy Taylor
, UK-London & Christa Thöne-Reineke, DE-Berlin
HALL 2
   
11:00-11:18   Barriers to the implementation of refinements in animal laboratories
Katy Taylor, UK-London 
11:18-11:36   Refinement strategies in experimental autoimmune encephalomyelitis (EAE) in mice
Kristina Ullmann, DE-Berlin
11:36-11:54   Community guidelines on animal studies - ALS research as a case-study
Nuno Henrique Franco
, PT-Porto
11:54-12:12   The role of the animal welfare officer on the 3R´s principle in laboratory animal science in Germany
Christa Thöne-Reineke
, DE-Berlin
12:12-12:30   Ethics review of animal experiments in Europe under Directive 2010/63/EU
Anna Olsson
, PT-Porto
12:30-13:30   Business lunch (to be served at the congress venue) and posters
12:30-13:30   ecopa General Assembly (members only)
Scientific sessions 13:30-15:00
3.2: 3D Models II
Chairs: Christoph Giese, DE-Berlin & Jens Kelm, CH-Schlieren
HALL 1    
13:30-13:48   The HuALN model for testing immune reactivity in vitro
Christoph Giese, DE-Berlin
13:48-14:06   Optimization of an eye irritation assay for hazard identification and labelling of materials to address the EU Cosmetic Directive and REACH Legislation
Yulia Kaluzhny, US-Ashland MA
14:06-14:24   Versatile, polymer-based devices for multi-parameter in vitro toxicology
Roisin Owens, FR-Gardanne
14:34-14:42   A microfluidics integrated electronic monitoring system of a 3D in vitro model of the renal tubule
Vincenzo Curto, FR-Gardanne
14:42-15:00   Omnisphero: A novel computational approach for high content image analyses (HCA) of organoid neurosphere cultures in vitro
Martin Roland Schmuck, DE-Düsseldorf
8: Inhalation
Chairs: Rodger Curren, US-Gaithersburg MD & Samuel Constant, CH-Geneva
HALL 3
   
13:30-13:50   Cellular human based systems for investigating the toxicity effects of inhalable substances
Samuel Constant, CH-Geneva
13:50-14:10   Systems Toxicology-based assessment of aerosols using human organotypic tissue cultures of nasal and bronchial epithelium
Julia Hoeng
, CH-Lausanne
14:10-14:30   Characterization of 3D reconstructed human airway models used for biomarker and inflammatory response studies
Rodger Curren, US-Gaithersburg MD
14:30-14:45   Preliminary validation studies of a 3D in vitro inhalation model, using cytokine and gene expression responses to metal-oxide particles
Ingeborg Kooter, NL-Utrecht
14:45-15:00   Building a framework of communication between industry and regulators to identify in vitro methods suitable for tobacco regulatory science
Erin Hill, US-Gaithersburg MD
5.1: QSAR & Read Across I - Read Across
Chairs: Matthias Herzler, DE-Berlin & Karel de Raat, FI-Helsinki
HALL 2
   
13:30-14:00   Preventing unnecessary testing by means of read-across: scope, justification and assessment
Karel de Raat
, FI-Helsinki 
14:00-14:20   New tools to assist in the application of the read-across approach
Alessandra Roncaglioni
, IT-Milano 
14:20-14:35   VPA Read across: Development of predictive biomarkers by using toxicity data of structurally similar compounds
Regina Stöber
, DE-Hannover 
14:35-15:00   Metabolomics as a read across tool
Tzutzuy Ramirez
, DE-Ludwigshafen 
15:00-15:30   Coffee break and posters  
Scientific sessions 15:30-17:00   
16.1: Refinement I and Culture of Care
Chairs: Susanna Louhimies, BE-Brussels & Kirsty Reid, BE-Brussels   
HALL 2
   
15:30-15:50   Working together to develop and implement a 'culture of care'
Kirsty Reid, BE-Brussels 
15:50-16:10   Pain Management and post-operative monitoring and care of laboratory rodents in Germany – lessons learnt and recommendations to improve practice
Kathrin Herrmann
, DE-Berlin 
16:10-16:30   Ending severe suffering: the scientific animal welfare organization as a catalyst for change
Elliot Lilley
, UK-Horsham 
16:30-16:50   Refinement facilitated by the Culture of Care
Susanna Louhimies
, BE-Brussels 
17.2: Replacement II
Chairs: Thomas Hartung, US-Baltimore MD & Stefanie Schindler, CH-Zurich
HALL 3
   
15:30-15:50   3D biocompatibility test systems mimicking the in vivo situation: evaluation of a hydroxyapatite-nanoparticular paste
Veronika Hruschka
, AT-Vienna
15:50-16:10   A mismatch between micro-motives and macro-behaviour: The inefficiency of efforts toward replacement at the individual level
Jan Lauwereyns
, JP-Fukuoka
16:10-16:35   New guidance on information requirements for skin corrosion/irritation and serious eye damage/eye irritation under REACH
Bohumila Bichlmaier Suchanová
, FI-Helsinki
16:35-17:00   Replacement – coming closer to a dream
Thomas Hartung
, US-Baltimore MD
19.1: Young Scientists Short Lectures I
Chairs: Helena Kandarova, SK-Bratislava & Manfred Liebsch, DE-Königs Wusterhausen     
HALL 1    
15:30-15:42   A 3D in vitro iPSC derived mini-brain model to study Parkinson’s disease
David Pamies, US-Baltimore MD 
15:42-15:54   Molecular modelling of osteoarthritis – evaluating pathways in vitro
Annemarie Lang, DE-Berlin 
15:54-16:06   A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology
Sebastian Konzok, DE-Hannover 
16:06-16:18   Impaired skin barrier function of cutaneous squamous cell carcinoma
Christopher Wolff, DE-Berlin 
16:18-16:30   Generation of 3D neurospheres from human induced pluripotent stem cells as an alternative in vitro method to study neurodevelopmental defects of Cockayne Syndrome patient
Maxi Hofrichter, DE-Düsseldorf 
16:30-16:42   Human lymphoblastoid cell lines as an in vitro tool in preclinical drug evaluation
Tijana Markovic, SI-Ljubljana 
16:42-16:54   Systematic assessment of different computational approaches for prediction of toxic effects of new chemical structures
Priyanka Banerjee
, DE-Berlin
17:00-19:00   Poster session II with coffee - authors present
Survey of the posters with presence of the authors
 
19:30   Departure to the Social Evening
20:00   Social Evening
Wednesday, 23 September 2015 
Scientific session 09:00-10:30
12.3: Disease Models III: Inflammation
Chairs: Katherina Sewald, DE-Hannover & Manfred Liebsch, DE-Königs Wusterhausen  
HALL 1    
09:00-09:20   Modular human biochip-based organoid models in sepsis research
Alexander Mosig, DE-Jena 
09:20-09:40   Use of ex vivo organotypic lung tissue in translational research of respiratory injury and inflammation diseases
Katherina Sewald, DE-Hannover
09:40-09:55   Evaluation of selumetinib and trametinib MEK inhibitors antitumor efficacy in a preclinical in vitro human lung cancer model
Samuel Constant, CH-Geneva
09:55-10:10   Phenotypic responses of human asthmatic airway epithelial cultures to rhinovirus and poly(I:C)
Patric Hayden, US-Ashland MA
10:10-10:30   Small Airway-on-a-Chip: A novel human inflammatory disease model
Kambez Benam, US-Boston MA
10:30-11:00   Coffee break and posters  
Scientific sessions 11:00-12:30
13: Biobarriers
Chairs: Brunhilde Blömeke, DE-Trier & Maike Windbergs, DE-Saarbrücken
HALL 3
   
11:00-11:15   Biophysical and metabolic properties of striae distensae evaluated ex vivo compared to normal skin
Youna Coquin, FR-Saint Gregoire
11:15-11:30   Assess the bio-barrier function of the human respiratory system using an in vitro 3D model of airway epithelial model (MucilAir™)
Samuel Constant, CH-Geneva
11:30-11:45   Intelligent inserts as scaffolds for functional cell co-culture models on a biomimetic scale
Silvia Angeloni, CH-Neuchâtel
11:45-12:00   In vitro models of skin wounds – potential, limitations and perspectives
Maike Windbergs, DE-Saarbrücken
12:00-12:15   Epithelial-endothelal co-cultures to mimic the air-blood-barrier
Brunhilde Blömeke, DE-Trier
 12:15-12:30   What happens when the particle has landed? – In vitro models for studying post-deposition events of aerosolized particles
Marius Hittinger, DE-Saarbrücken 
19.2: Young Scientists Short Lectures II
Chairs: Helena Kandarova, SK-Bratislava & Lucia Lu Lee, DE-Berlin/CN-Hong Kong & Manfred Liebsch, DE-Königs Wusterhausen
HALL 1    
11:00-11:12   Chip-based co-culture of neurospheres and liver spheroids for long-term substance testing
Anja Ramme, DE-Spreenhagen
11:12-11:24   Human in vitro Blood-Brain Barrier model generated from stem cells: reducing attrition in the Central Nervous System area
Aurore Drolez, FR-Lens
11:24-11:36   A microfluidic four-organ-chip – a potential tool for ADME profiling
Juliane Hübner, DE-Berlin
11:36-11:48   In vitro investigation on uptake, cytotoxicity and genotoxicity of two similar sized titanium oxide nanoparticles on the human hepatic cells HepaRG
Pegah Jalili, FR-Fougeres
11:48-12:00   Optimization of a new in vitro method for inhalation toxicology and its application for the study of zinc oxide nanoparticle toxicity
Emilie Da Silva, DK-København
12:00-12:12   Assessment of sensitization and photosensitization of benzophenone-3 based on DPRA
Carolina Benevenuto, BR-Brazil
12:24   Closing Remarks and YSTA Lecture Award
     
13:30-17:45   Day 1: EUSAAT 2015 Practical Training Course on Alternative Methods 
13:30-18:00   Part 1: SET Workshop "Translational Aspects of in vitro and in vivo Models for Inflammatory Diseases" (participation on invitation only) 
Thursday, 24 September 2015   
09:00-13:00   Day 2: EUSAAT 2015 Practical Training Course on Alternative Methods  
09:00-15:00     Part 2: SET Workshop "Translational Aspects of in vitro and in vivo Models for Inflammatory Diseases" (participation on invitation only)  

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