20th European Congress on Alternatives to Animal Testing, August 24-27 2016, University of Linz, Austria

Program by days

(prel. v. 22.08.2016)

Download the abstractbook here (higher resolution, 55 mb). Or with a lower resolution here (3 mb).

Wednesday, 24 August 2016
Opening & keynote lecture 13:00-13:45
HALL 1    
    Welcome addresses
Ellen Fritsche
, DE-Duesseldorf, President of EUSAAT
Horst Spielmann, DE-Berlin
13:00-13:15   25th Anniversary of the European Congresses on Alternatives to Animal Testing in Linz, Austria
Horst Spielmann, DE-Berlin
13:15-13:45   The 3Rs in relation to REACH
Derek Knight, FI-Helsinki
Scientific sessions 13:50-15:20
1 EU 3Rs Projects in Toxicology & other 3Rs Funding Institutions
Chairs: Ellen Fritsche
, DE-Duesseldorf & Horst Spielmann, DE-Berlin
13:50-14:20   SEURAT-1: A cluster of European projects that have changed the landscape for 21st century European toxicology
Andrea-Nicole Richarz, IT-Ispra
14:20-14:50   The EU-ToxRisk project: A European flagship program for mechanism-based safety sciences and risk assessment
Mardas Daneshian, DE-Konstanz
14:50-15:05   The Lush Prize - an overview
Rebecca Ram, UK-Manchester
15:05-15:20   A retrospective on 40 years of funding animalfree methods
Stefanie Schindler, CH-Bern
8.1 Replacement of Animals in Research & Use of Non-Animal Methods and Technologies - NEW Non-Animal Methods
Chairs: Candida Nastrucci
, IT-Rome & Mardas Daneshian, DE-Konstanz
13:50-14:05   Replacement and Non-Animal Methods: The importance to be the change
Candida Nastrucci
, IT-Rome
14:05-14:20   The process of isolation and characterisation of HUIEC - Human Intestinal Epithelial Cell Line
Lidija Gradišnik, SL-Slovenia
14:20-14:35   Intestinal organoids: Functional studies on nutrient and drug transport, hormone secretion and intracellular signaling
Tamara Zietek, DE-Munich
14:35-14:50   Replacement of goat xenobiotic metabolism studies beyond OCED 503 by use of rumen simulation technique (RUSITEC)
Barbara Birk, DE-Ludwigshafen 
14:50-15:05   Impact of New Technologies on Malignant Tumor Management and Therapy
Lukas Kenner, AT-Vienna
15:05-15:20   Three Rs in endocrine disruptor assessment – Refining sampling, reducing numbers of tested animals and replacing in vivo testing
Reinhard Möller, DE-Aarbergen
HALL 3    
10.1 Toxicology I - Systemic Toxicity & Environmental Toxicity
Chairs: Stephanie Bopp
, IT-Ispra & Erwin Roggen, DK-Kongens Lyngby
13:50-14:10   EPAA contributions in the area of ADME and carcinogenicity testing
Renate Weissenhorn, BE-Brussels
14:10-14:30   Perspectives to use the fish embryo test for applications beyond acute toxicity prediction – chronic fish toxicity, endocrine disruption and developmental toxicity
Stefan Scholz, DE-Leipzig
14:30-14:45   Human or mouse fibroblasts for assessing acute toxicity? 
Tuula Heinonen, FI-Tampere
14:45-15:00   A medium-throughput method for the analysis of (combinatorial) endocrine effects using the nematode C. elegans
Silvia Vogl, DE-Berlin
15:00-15:20   Exposure-Based Chemical Safety Assessment Workflow Integrating Alternative Methods: An Ab Initio Case Study for Repeated-Dose Toxicity 
Andrea-Nicole Richarz
, IT-Ispra
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15:20-17:20   SEMINAR Classification and Reporting of Severity - date option I
more details
open to all participants of the EUSAAT 2016 Congress & open to external participants
- number of participants limited

15:20-15:50   Coffee break and posters
Scientific sessions 15:50-17:20  
2 Global Cooperation on Implementing the 3Rs
Chairs: Jarlath Hynes
, BE-Brussels & Hajime Kojima, JP-Tokyo
15:50-16:10   The current status of non-animal test methods and prospects for Asian cooperation
Hajime Kojima, JP-Tokyo
16:10-16:30   The current status of nonanimal alternatives in the life sciences in China
Mao Ling Wei, CN-Chengdu
16:30-16:50   Examination of the gap between validation and (real) regulatory acceptance
Erin Hill, US-Gaithersburg
16:50-17:05   Norecopa: providing global 3R-resources for animal research
Adrian Smith, NO-Oslo
17:05-17:20   MAD world? Promoting the greater mutual acceptance of data
Jarlath Hynes, BE-Brussels
13.2 Disease Models in vitro versus in vivo - Skin & ex vivo Tissues
Chairs: Sarah Hedtrich
, DE-Berlin & Roman Kolar, DE-Neubiberg
15:50-16:10   Inflammatory skin disease models
Sarah Hedtrich, DE-Berlin
16:10-16:30   An inflammatory, filaggrin-deficient skin model demonstrates hallmarks of atopic dermatitis in vitro
Stefan Hönzke, DE-Berlin 
16:30-16:50   Novel perspectives for in vitro models of human skin wounds
Maike Windbergs, DE-Saarbrücken
16:50-17:05   Fast and label-free tracking of cell behavior in non-animal models
Karin Schütze, DE-Bernried
17:05-17:20   Preclinical evaluation of CD30 as a novel molecular target in systemic mastocytosis
Peter Valent, AT-Vienna
14.1 3Rs in Education and Academia - Academia
Chairs: Monika Schäfer-Korting
, DE-Berlin & Christa Thöne-Reineke, DE-Berlin
15:50-16:15   BB3R – educating the next generation of scientists
Monika Schäfer-Korting, DE-Berlin
16:15-16:35   ReThink3R – innovation strategies for young scientists – Report of the first workshop
Annemarie Lang, DE-Berlin
16:35-16:50   CAAT Academy: From inception to launching
Francois Busquet, BE-Ixelles
16:50-17:05   A Course in Replacement Alternatives: To give the good example
Candida Nastrucci, IT-Rome
17:05-17:20   Improving transparency on quality and translatability of animal studies using new science driven approach
Judith van Luijk, NL-Nijmegen
Round table I 17:25-18:25 
HALL 1    
17:25-18:25   "Building a career in the 3Rs area: successful biotech SMEs"
Rodger Curren
, IIVS, US-Gaithersburg
Samuel Constant, Epithelix & OncoTheis Sàrl, CH-Geneva
Helena Kandarova, MatTek IVLSL, SK-Bratislava
Jems Kelm, InSphero AG, CH-Schlieren
Reyk Horland, TissUse GmbH, DE-Berlin
Dmitry Sakharov, Bioclinicum Research Centre, Acad. Sciences, RU-Moscow
18:30   Welcome reception (at the congress venue)
Thursday, 25 August 2016
Keynote lecture 09:00-09:30   
09:00-09:30   Real world medicine and real world patients: Something that animal testing can never approximate
Michael Liebmann, US-Kennett Square
Scientific sessions 09:35-11:05  
HALL 1    
4 Implementing Dir 2010/63/EU
Chairs: Susanna Louhimies
, BE-Brussels & Gilbert Schönfelder, DE-Berlin
09:35-09:55   The role of the National Committees (NC) and Animal Welfare Bodies (AWB) under Directive 2010/63/EU
Susanna Louhimies, BE-Brussels
09:55-10:10   Towards a harmonized approach: Role of the German National Committee for the Protection of Animals Used for Scientific Purposes in the process of implementation of the Directive 2010/63/EU
Justyna Chmielewska, DE-Berlin
10:10-10:25   Role of the Swedish national committee in the harmonization of project authorization and evaluation
Katarina Cvek, SE-Uppsala
10:25-10:40   Establishing a culture of care by implementing AUGUST – a new and strong initiative at Aarhus University
Birgitte Kousholt, DK-Aarhus N
10:40-10:55   From the guideline to the bench – The role of science based policy advice in implementing EU Dir 63/2010 in Germany
Henning Steinicke, DE-Halle
10:55-11:10   Animal welfare requirements – significant room for improvement
Irmela Ruhdel
, DE-Neubiberg
5.1 Novel Approaches in Efficacy and Safety Testing – 3D models I
Jens Kelm, CH-Zurich & Joachim Wiest, DE-Munich
09:35-09:55   A three-dimensional bioprinted liver equivalent for human-on-a-chip toxicity screenings
Tobias Grix, DE-Berlin
09:55-10:15   Studying liver toxicity and disease modelling using bioprinted 3D human liver tissue
Christine Daly, UK-London
10:15-10:35   Hepatic differentiation of hiPSC in co-culture with endothelial cells using different culture media
Nora Freyer, DE-Berlin
10:35-10:50   In vitro study of melatonin effect on HepG2 cells treated with IL-6 in newly developed liver on chip device
Mi Jang, DE-Saarbruecken
10:50-11:05   A modular cell sheet-based approach towards 3D tissue models
Marie Weinhart, DE-Berlin
9.1 Predictive Toxicology - QSAR & Testing Strategies
Chairs: Robert Landsiedel
, DE-Ludwigshafen & Magdalini Sachana, FR-Paris
09:35-09:55   OECD projects on Integrated Approaches to Testing and Assessment (IATA): a combination of mechanistic information and alternative methods to improve predictive toxicology
Magdalini Sachana, FR-Paris
09:55-10:15   EuroMix: using (Q)SARs, TTC, molecular docking simulation and read across as a first tier in mixture toxicity risk assessment
Emiel Rorije, NL-Bilthoven
10:15-10:35   A decision-making framework for the grouping and testing
Josje Arts, NL-Arnhem
10:35-10:50   A High Accuracy QSAR based on rabbit data to predict the human skin and eye irritation potential of individual constituents and mixtures
Faizan Sahigara, FR-L’Isle D’Abeau
10:50-11:05   Computational profiling as a proxy for drug hazard prediction in pharmaceutical research
Friedemann Schmidt, DE-Frankfurt
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11:15-13:15   SEMINAR Classification and Reporting of Severity - date option II
more details
open to all participants of the EUSAAT 2016 Congress & open to external participants
 - number of participants limited

11:05-11:30   Coffee break and posters 
Scientific sessions 11:30-13:00
5.2 Novel Approaches in Efficacy and Safety Testing – 3D models II
Chairs: Samuel Constant, CH-Plan-les-Ouates & Ellen Fritsche, DE-Duesseldorf
11:30-11:55   OncoCilAir™: Organotypic human in vitro model for lung cancer research
Samuel Constant, CH-Plan-les-Ouates
11:55-12:15   Migrating to the 3rd dimension: the “Neurosphere Assay” to study migration disturbances during neurodevelopment
Marta Barenys, DE-Duesseldorf
12:15-12:35   The 'Neurosphere Assay' as a valuable part of a DNT testing strategy
Ellen Fritsche, DE-Duesseldorf
12:35-12:55   ATERA: advanced 3D human tissue models and exclusive testing services for cosmetic, consumer product and pharmaceutical industry
Bart De Wever, LU-Esch-sur-Alzette
6.1 Stem Cells & Reproductive Toxicity (including mEST & hEST) - Stem Cells
Chairs: Jürgen Hescheler
, DE-Köln & Ole Pless, DE-Hamburg
11:30-11:50   Cardiotoxicity gene and miRNA biomarkers induced by anticancer drugs
Agapios Sachinidis, DE-Cologne
11:50-12:10   Practical application of human iPS cells for chemical toxicity assessment
Yasunari Kanda, JP-Tokyo
12:10-12:30   A hiPSC-based test platform (DropTech®) for toxicity assessment of small molecule compounds in early stage drug discovery
Ole Pless, DE-Hamburg
12:30-12:45   Replacing animal testing by genotoxicity and carcinogenic cell transformation assessment using a tissue regenerating cell line from fish with GFP-labelled histones
Petra Stahlschmidt-Allner, DE-Aarbergen
12:45-13:00   A stem cell based metabolic activation system – Potential for replacing rat liver S9 fraction
Cristiano F. Lerche
, DE-Aarbergen
12 Efficacy of Drugs, Biologiocals & Vaccines
Chairs: Tuula Heinonen
, FI-Tampere & Katrin Schutte, BE-Brussels
11:30-11:50   Towards global harmonisation of 3Rs in biologicals
Katrin Schutte, BE-Brussels
11:50-12:10   The “BINACLE” (binding and cleavage) assay allows in vitro determination of botulinum and tetanus neurotoxin activity
Heike Behrensdorf-Nicol, DE-Langen
12:10-12:30   G-protein based ELISA as a potency test for human rabies vaccines
Martine Chabaud-Riou, FR-Marcy l'Etoile
12:30-12:45   Development, optimization and validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model Epiderm
Helena Kandarova, SK-Bratislava
12:45-13:00   Animal Friendly Affinity Reagents (AFAs): making animal immunisation obsolete
Alison Gray, FR-Morzine
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13:00-14:00   Business lunch (to be served at the congress venue) and posters
Scientific sessions 14:00-15:30
3 Ethical and Legal Issues
Chairs: Roman Kolar
, DE-Neubiberg & Katy Taylor, UK-London

14:00-14:15   An ethical challenge to the normalisation of animal experimentation
Kay Peggs, UK-Winchester
14:15-14:30   A proposal for a catalogue of criteria to objectify the harm-benefit analysis of proposed projects including animal experiments
Norbert Alzmann, DR-Tuebingen 
14:30-14:45   Applying the harm benefit assessment under the EU Directive – what does it mean in practice for animals?
Katy Taylor, UK-London 
14:45-15:00   Biotechnological chimeras and experimentation: legislative lacunae legerdemain?
Maureen O'Sullivan, IR-Galway 
15:00-15:15   Ethical aspects of the Crispr/Cas9 technology
Henriette Bout, NL-Amsterdam
15:15-15:30   Non-human primates in neuroscience research: Can it be ethical, if it isn’t scientifically necessary?
Jarrod Bailey, UK-London
7.1 Refinement & Welfare: Culture of Care & Best Practice Approaches
Chairs: Susanna Louhimies
, BE-Brussels & Christa Thöne-Reineke, DE-Berlin
14:00-14:15   Implementation of 3Rs for livestock animals in bioscientific research-rationale and objectives of the newly established expert working group – LaNiV
Fabienne Ferrara, DE-Berlin 
14:15-14:30   Group housing of rats and rabbits - Thinking out of the box
Kerstin Kleinschmidt-Dörr, DE-Darmstadt 
14:30-14:45   Refinement and reduction strategies in experimental stroke
Christa Thöne-Reineke, DE-Berlin
14:45-15:00   The drinking water as application route for pain management in bone-linked mice models – Combining a refinement and a basic research study
Annemarie Lang, DE-Berlin
15:00-15:15   Assessing laboratory mouse welfare using animal-based measures
Elin Spangenberg, SE-Uppsala
15:15-15:30   Reducing animal numbers by half: A hybrid preparation technique for the simultaneous investigation of histology and broncho-alveolar lavage parameters of the rat lung
Martin Wiemann, DE-Muenster 
13.1 Disease Models in vitro versus in vivo - Lung Infections
Chairs: Samuel Constant, CH-Plan-les-Ouates & Claus Michael Lehr, DE-Saarbruecken
14:00-14:20   Modeling severe infection in human lung tissue
Katja Zscheppang, DE-Berlin 
14:20-14:40   The use of in vitro human airway epithelia for the development of novel antivirals
Samuel Constant, CH-Plan-les-Ouates
14:40-15:00   Novel cystic fibrosis in vitro model for safety and efficacy testing of new drug delivery systems against chronic Pseudomonas aeruginosa infections
Jenny Juntke, DE-Saarbruecken 
15:00-15:15   Transient receptor potential (TRP) ion channels activation induce increased bronchoconstriction in passive sensitized vital human ex vivo precision-cut lung slices
Susann Dehmel, DE-Hannover 
15:15-15:30   Modeling fungal infections within a three-dimensional perfused respiratory system
Doris Wilflingseder, AT-Innsbruck 
15:30-16:00   Coffee break and posters  
Round table II 16:00-17:00      
HALL 1    
16:00-17:00   Implementing the concept of "Integrated Approaches to Testing and Assessment (IATA)" into international regulatory testing
Horst Spielmann
, FU Berlin & EUSAAT, DE-Berlin
Stephanie Bopp
Rodger Curren
, IIVS, US-Gaithersburg
Derek Knight
, ECHA, FI-Helsinki
Robert Landsiedel
, BASF, DE-Ludwigshafen
Magdalini Sachana
, OECD, FR-Paris
Stefan Scholz
, UFZ Helmholtz Centre, DE-Leipzig
17:00-19:00   Poster session I with coffee - authors present
Survey of the posters with presence of the authors
HALL 2    
19:15-20:30   Annual General Assembly of EUSAAT (members only)
Friday, 26 August 2016
Keynote lecture 09:00-09:30  
09:00-09:30   Combating infectious diseases, novel approaches and in vitro models
Claus-Michael Lehr
, DE-Saarbruecken
Scientific sessions 09:35-11:05
HALL 1    
5.3 Novel Approaches in Efficacy and Safety Testing – Multi-Organ-Chips I
Chairs: Mark Rosowski
, DE-Berlin & Dmitry Sakharov, RU-Moscow
09:35-09:55   From organoid technology to Multi-Organ-Chip development for substance testing
Mark Rosowski, DE-Berlin 
09:55-10:15   Increasing biological relevance in vitro: From single microtissues to micro-physiological systems
Jens Kelm, CH-Zurich 
10:15-10:35   Creating organotypic oxygen tension in cell culture chambers using perfused flow and flexible chamber geometry
Kelly Davidge, UK-Rotherham 
10:35-10:50   Online TEER measurements in Homunculus system for orally administered drugs testing
Dmitry Sakharov, RU-Moscow
10:50-11:05   Utilization of Hommunculus platform for evaluation of cytochrome P450 activity in "liver-on-a-chip"
Andrey Poloznikov, RU-Moscow 
8.2 Replacement of Animals in Research & Use of non-Animal Methods and Technologies - Serum Free Media
Chairs: Stefanie Schindler, CH-Bern & Jan van der Valk, NL-Utrecht
09:35-10:00   Serum-free media and serum alternatives
Jan van der Valk, NL-Utrecht 
10:00-10:20   Towards the replacement of fetal bovine serum in cell culture applications
Christopher Fassbender, UK-London
10:20-10:40   A fetal bovine serum free cytotoxicity test following ISO 10993-5
Joachim Wiest, DE-Munich
10:40-11:00   IONOSENSE POC: Integration of OECTs with live cells an a 12-well plate for in vitro diagnostics,
Aimie Pavia, FR-Gardanne
11.1 Toxicology II - Skin Sensitization, Phototoxicity
Chairs: Silvia Letasiova
, SK-Bratislava & Klaus R. Schröder, AT-Linz
09:35-09:55   Assessment of pre- and pro-haptens using non-animal test methods for skin sensitization
Britta Wareing, DE-Ludwigshafen 
09:55-10:15   Extending the limits of the hCLAT assay – test of the sensitization potential of oxidative hair dyes
Karsten Mewes, DE-Duesseldorf
10:15-10:35   GARD – the future of sensitization testing using a genomics-based platform
Anki Malmborg Hager, SE-Lund 
10:35-10:50   ITS for skin sensitization potential – 1 out of 2 or 2 out of 3?
David Roberts, UK-Liverpool 
10:50-11:05   An improved reactive oxygen species assay for photosafety assessment of chemicals with limited aqueous solubility
Yoshiki Seto
, JP-Shizuoka 
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11:15-13:15   SEMINAR Classification and Reporting of Severity - date option III
more details
open to all participants of the EUSAAT 2016 Congress & open to external participants
REGISTRATION REQUIRED - number of participants limited

11:05-11:30   Coffee break and posters
Scientific sessions 11:30-13:00  
HALL 1    
5.4 Novel Approaches in Efficacy and Safety Testing – Multi-Organ-Chips II
Chairs: Reyk Horland
, DE-Berlin & Helena Kandarova, SK-Bratislava
11:30-11:50   Bringing a human heart & fat on a chip: microphysiological platforms as in vitro models of cardiac and adipose tissue
Peter Loskill, DE-Stuttgart 
11:50-12:10   High-throughput microfluidic platform for culture of 3D-kidney tissue models
Henriëtte Lanz, NL-Leiden 
12:10-12:30   Towards lung disease-on-chip models and personalized medicine application
Colette Bichsel, CH-Bern 
12:30-12:45   Vascularization of Multi-Organ-Chips for tissue engineering and regenerative medicine
Severin Mühleder, AT-Vienna 
12:45-13:00   Opportunities for Organ-on-a-Chip models in toxicological risk assessment
Minne Heringa, NL-Bilthoven 
7.2 Refinement & Welfare: Avoidance of Severe Suffering
Chairs: Jana Keller
, DE-Ludwigshafen & Katy Taylor, UK-London
11:30-11:50   Focus on severe suffering: an update on RSPCA activity to end severe suffering
Elliot Lilley, UK-Horsham 
11:50-12:10   Systematic reviews of animal studies equal the implementation of the 3Rs
Merel Ritskes-Hoitinga, NL-Nijmegen
12:10-12:30   A proposal for a table to support the classification of the overall severity of a proposed project including animal experiments
Norbert Alzmann, DE-Tuebingen
12:30-12:45   How to determine severity degrees for genetically altered rodents?
Anne Zintsch, DE-Berlin
12:45-13:00   Repeated isoflurane anesthesia in female mice–Assessing the severity of stress
Katharina Hohlbaum, DE-Berlin 
14.2 3Rs in Education and Academia - Education
Chairs: Monika Schäfer-Korting
, DE-Berlin & Christa Thöne-Reineke, DE-Berlin
11:30-11:50   Teaching practical applications of animal welfare – a review over 10 years of the FELASA B-Course in Vienna
Christiane Winding, AT-Vienna 
11:50-12:10   Education and Training Platform for Laboratory Animal Science (ETPLAS)
Jan van der Valk, NL-Utrecht
12:10-12:30   Development and establishment of an interdisciplinary international master program for laboratory animal science (MLAS): a contribution to the 3R principles
Julia Steitz, DE-Aachen 
12:30-12:45   Advanced training course for veterinarians to qualify for Animal Welfare Officer
Christa Thöne-Reineke, DE-Berlin 
12:45-13:00   Establishment of an education program that meets the needs of researchers and animals
Jan Baumgart, DE-Mainz 
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13:00-14:00   Business lunch (to be served at the congress venue) and posters
Scientific sessions 14:00-15:30
HALL 1    
6.2 Stem Cells & Reproductive Toxicity (including mEST & hEST) - EST
Chairs: Hajime Kojima
, JP-Tokyo & Horst Spielmann, DE-Berlin
14:00-14:20   Hand1-Luc Embryonic stem cell test (Hand1-Luc EST): A reporter gene assay using engineered mouse ES cells to evaluate embryotoxicity in vitro
Florian Le Coz, JP-Osaka 
14:20-14:40   Automation-compatible EST assay
Simon Ströbel, CH-Schlieren
14:40-15:00   Prediction of relative developmental toxicity of antifungal compounds using the ES-D3 cell differentiation assay, combined with the BeWo transport model
Hequn Li, UK-Sharnbrook 
15:00-15:15   Tests for the safety evaluation of a Chinese herbal medicine formula used in the treatment of atopic dermatitis
Lucia Lu Li, CN-Hangzhou 
15:15-15:30   Good Cell Culture Practice for stem cells, stem-cell-derived models and organ-on-chip models
Mardas Daneshian, DE-Konstanz 
10.2 Toxicology I - Inhalation Toxicity
Chairs: Rodger Curren
, US-Gaithersburg & Julia Hoeng, CH-Neuchatel
14:00-14:15   Evaluation of reconstituted human bronchial epithelium (MucilAir™) suitability for repeated dose testing
Samuel Constant, CH-Plan-les-Ouates 
14:15-14:30   Metaplastic phenotype in human primary bronchiolar epithelial cells after repeated exposure to mainstream cigarette smoke at the air-liquid interface
Michaela Aufderheide, DE-Hannover
14:30-14:45   Establishment and charakterization of a lung/liver organ-on-a-chip model. Phase 1: Model charakterization
David Bovard, CH-Neuchâtel 
14:45-15:00   Development of an in vitro inhalation toxicity test with potential regulatory applicability
Anna Maione, US-Ashland MA
15:00-15:15   Collaborative industry efforts to optimize and standardize in vitro methods suitable for tobacco regulatory science
Erin Hill, US-Gaithersburg MD 
15:15-15:30   Novel Aerosol exposure devices for in-vitro toxicity testing at the air/liquid interface
Tobias Krebs, DE-Waldkirch 
13.3 Disease Models in vitro versus in vivo - Other Organs
Chairs: Stefanie Schindler
, CH-Bern & Sven Schnichels, DE-Tuebingen
14:00-14:20   A human neuronal in vitro model for application in biomedical research and in pharmacological and toxicological investigations
Stefan Schildknecht
, DE-Konstanz 
14:20-14:40   3D in vitro tissue models for infection studies with human pathogens
Matthias Schweinlin
, DE-Wuerzburg
14:40-15:00   Retinal organotypic cultures as disease model for ophthalmic diseases – recently proposed models
Sven Schnichels, DE-Tuebingen
15:00-15:15   Analysis of a novel ex vivo organ model to simulate neurodegeneration in retina
Stephanie Joachim, DE-Bochum 
15:15-15:30   Recent developments of disease and human in vitro models of the blood-brain barrier
Winfried Neuhaus, AT-Vienna 
15:30-16:00   Coffee break and posters  
Scientific sessions 16:00-17:30   
9.2 Predictive Toxicology - Read Across
Chairs: Stephanie Bopp
, IT-Ispra & Eric Stilgenbauer, FI-Helsinki
16:00-16:20   The use of metabolomics in vivo as read across tool: a case study with phenoxy carboxylic acid herbicides
Hennicke Kamp, DE-Ludwigshafen 
16:20-16:40   Supporting evidence in read across approaches: potential and limitations of new approaches and methodologies
Eric Stilgenbauer
, FI-Helsinki
16:40-17:00   Improving confidence in read across: A case study for the oral repeated dose toxicity of β-Olefinic alcohols
Mark Cronin, UK-Liverpool
17:00-17:15   Simulating chemical kinetics and dynamics for the prediction of toxicity
Alicia Paini, IT-Ispra 
17:15-17:30   New possibilities in mathematical toxicology
Marko Raseta, UK-York 
11.2 Toxicology II - Bio-barriers & Novel Testing Concepts
Chairs: Claus Michael Lehr
, DE-Saarbruecken & Erin Hill, US-Gaithersburg
16:00-16:20   Cellular and non-cellular elements of the pulmonary air-blood barrier
Claus-Michael Lehr, DE-Saarbruecken 
16:20-16:40   BioVaSc-TERM - a platform technology to engineer human barrier models
Angela Rossi, DE-Wuerzburg
16:40-16:55   The novel ToxTracker reporter system provides mechanistic insight into the genotoxic properties of compounds and materials
Giel Hendriks, NL-Leiden
16:55-17:10   Integration of conducting polymer devices with 3D human tissue models for in vitro toxicology testing
Magali Ferro, FR-Gardanne 
17:10-17:30   If non-animal alternative tests are accepted by regulatory agencies, will industry use them?
Rodger Curren, US-Gaithersburg MD 
13.4 Disease Models in vitro versus in vivo - Using Data Bases & Information Tools
Chairs: Brigitte Landesmann
, IT-Ispra & Gilbert Schönfelder, DE-Berlin
16:00-16:25   Defining the optimal animal model for translational research using gene set enrichment analysis
Matthias Steinfath, DE-Berlin 
16:25-16:50   Modernizing law and policy to support innovation in preclinical pharmaceutical testing in the United States
Elizabeth Baker, US-Washington 
16:50-17:15   From bedside to bench – adding human context to in vitro models
Brigitte Landesmann, IT-Ispra 
17:30-19:00   Poster session II with coffee - authors present
Survey of the posters with presence of the authors 
19:30   Departure to the Social Evening
20:00   Social Evening
Saturday, 27 August 2016
Keynote lecture 09:00-09:30
09:00-09:30   The CRISPR/Cas9 sytstem: a game changer in the life sciences
Malte Spielmann
, DE-Berlin
Scientific sessions 09:30-11:15
15.1 Young Scientists Lectures I
Chairs: Lucia Lu Li
, CN-Hangzhou & Horst Spielmann, DE-Berlin
09:30-09:45   The use of human (non- 3D equivalent) skin assays (SkimuneTM) for the detection of adverse reactions, potency and efficacy
Ana Ribeiro, UK-Newcastle 
09:45-10:00   An in vitro system to predict the pro-fibrotic potential of carbon nanotubes in the lung
Hana Barosova
, CH-Fribourg 
10:00-10:15   Use of human derived liver cell lines for the detection of genotoxic carcinogens
Monika Waldherr, AT-Vienna 
10:15-10:30   Chronologically-aged fibroblasts significantly alter the morphology of reconstructed human skin
Christian Hausmann, DE-Berlin 
10:30-10:45   Three dimensional cell culture model for toxicity and efficacy tests
Karolin Fröhlich, DE-Jena
10:45-11:00   Development of an innovative moving interface for an in vitro model of the epithelial intestinal barrier
Joana Costa, IT-Massarosa
11:00-11:15   Label-free monitoring of HepG2 spheroids – a platform for automated liver toxicity screening
Sebastian Eggert, DE-Munich
 11:15-11:40   Coffee break and posters  
Scientific sessions 11:40-13:10
15.2 Young Scientists Lectures II
Chairs: Mardas Daneshian
, DE-Konstanz & Joachim Wiest, DE-Munich
11:40-11:55   Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization
Gerrit Müller, DE-Berlin 
11:55-12:10   A novel 3D in vitro model of the deep lung in both healthy and diseased state for screening of safety and efficacy of pulmonary (nano)medicines
Remi Hendrix, DE-Saarbruecken 
12:10-12:25   Effects of anti-tumor drugs bevacizumab and cisplatin on cancer cell invaded human ex vivo lung tissue in an organotypic model as an alternative to animal experiments
Sebastian Konzok, DE-Hannover 
12:25-12:40   Safety assessment in EU-substance law: An open door for alternative methods
Lena Hehemann, CH-Fribourg 
12:40-12:55   Litter loss as a neglected welfare problem?
Charlotte S. Leidinger, DE-Mainz 
12:55-13:10   Assessment of Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) for screening of anticancer activities of drugs
Mahmoud Galal, EG-Cairo 
13:10   Closing Remarks and YSTA Lecture Award
Saturday, 27 August 2016 



Day one - lectures
EUSAAT 2016 Practical Training Course on Alternative Methods: Application of commercially available human tissue models - more details

open to all participants of the EUSAAT 2016 Congress, registration required

Sunday, 28 August 2016




Day two - hands on
EUSAAT 2016 Practical Training Course on Alternative Methods: Application of commercially available human tissue models - more details

open to all participants of the EUSAAT 2016 Congress, registration required