Program by days
(prel. v. 22.08.2016)
Download the abstractbook here (higher resolution, 55 mb). Or with a lower resolution here (3 mb).
| Wednesday, 24 August 2016 | ||
| Opening & keynote lecture 13:00-13:45 | ||
| HALL 1 | ||
| Welcome addresses Ellen Fritsche, DE-Duesseldorf, President of EUSAAT Horst Spielmann, DE-Berlin |
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| 13:00-13:15 | 25th Anniversary of the European Congresses on Alternatives to Animal Testing in Linz, Austria Horst Spielmann, DE-Berlin |
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| 13:15-13:45 | The 3Rs in relation to REACH Derek Knight, FI-Helsinki |
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| Scientific sessions 13:50-15:20 | ||
| HALL 1 |
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| 1 EU 3Rs Projects in Toxicology & other 3Rs Funding Institutions Chairs: Ellen Fritsche, DE-Duesseldorf & Horst Spielmann, DE-Berlin |
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| 13:50-14:20 | SEURAT-1: A cluster of European projects that have changed the landscape for 21st century European toxicology Andrea-Nicole Richarz, IT-Ispra |
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| 14:20-14:50 | The EU-ToxRisk project: A European flagship program for mechanism-based safety sciences and risk assessment Mardas Daneshian, DE-Konstanz |
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| 14:50-15:05 | The Lush Prize - an overview Rebecca Ram, UK-Manchester |
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| 15:05-15:20 | A retrospective on 40 years of funding animalfree methods Stefanie Schindler, CH-Bern |
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| HALL 2 |
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| 8.1 Replacement of Animals in Research & Use of Non-Animal Methods and Technologies - NEW Non-Animal Methods Chairs: Candida Nastrucci, IT-Rome & Mardas Daneshian, DE-Konstanz |
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| 13:50-14:05 | Replacement and Non-Animal Methods: The importance to be the change Candida Nastrucci, IT-Rome |
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| 14:05-14:20 | The process of isolation and characterisation of HUIEC - Human Intestinal Epithelial Cell Line Lidija Gradišnik, SL-Slovenia |
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| 14:20-14:35 | Intestinal organoids: Functional studies on nutrient and drug transport, hormone secretion and intracellular signaling Tamara Zietek, DE-Munich |
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| 14:35-14:50 | Replacement of goat xenobiotic metabolism studies beyond OCED 503 by use of rumen simulation technique (RUSITEC) Barbara Birk, DE-Ludwigshafen |
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| 14:50-15:05 | Impact of New Technologies on Malignant Tumor Management and Therapy Lukas Kenner, AT-Vienna |
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| 15:05-15:20 | Three Rs in endocrine disruptor assessment – Refining sampling, reducing numbers of tested animals and replacing in vivo testing Reinhard Möller, DE-Aarbergen |
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| HALL 3 | ||
| 10.1 Toxicology I - Systemic Toxicity & Environmental Toxicity Chairs: Stephanie Bopp, IT-Ispra & Erwin Roggen, DK-Kongens Lyngby |
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| 13:50-14:10 | EPAA contributions in the area of ADME and carcinogenicity testing Renate Weissenhorn, BE-Brussels |
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| 14:10-14:30 | Perspectives to use the fish embryo test for applications beyond acute toxicity prediction – chronic fish toxicity, endocrine disruption and developmental toxicity Stefan Scholz, DE-Leipzig |
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| 14:30-14:45 | Human or mouse fibroblasts for assessing acute toxicity? Tuula Heinonen, FI-Tampere |
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| 14:45-15:00 | A medium-throughput method for the analysis of (combinatorial) endocrine effects using the nematode C. elegans Silvia Vogl, DE-Berlin |
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| 15:00-15:20 | Exposure-Based Chemical Safety Assessment Workflow Integrating Alternative Methods: An Ab Initio Case Study for Repeated-Dose Toxicity Andrea-Nicole Richarz, IT-Ispra |
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| 15:20-17:20 | SEMINAR Classification and Reporting of Severity - date option I more details open to all participants of the EUSAAT 2016 Congress & open to external participants REGISTRATION REQUIRED - number of participants limited |
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| 15:20-15:50 | Coffee break and posters | |
| Scientific sessions 15:50-17:20 | ||
| HALL 1 |
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| 2 Global Cooperation on Implementing the 3Rs Chairs: Jarlath Hynes, BE-Brussels & Hajime Kojima, JP-Tokyo |
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| 15:50-16:10 | The current status of non-animal test methods and prospects for Asian cooperation Hajime Kojima, JP-Tokyo |
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| 16:10-16:30 | The current status of nonanimal alternatives in the life sciences in China Mao Ling Wei, CN-Chengdu |
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| 16:30-16:50 | Examination of the gap between validation and (real) regulatory acceptance Erin Hill, US-Gaithersburg |
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| 16:50-17:05 | Norecopa: providing global 3R-resources for animal research Adrian Smith, NO-Oslo |
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| 17:05-17:20 | MAD world? Promoting the greater mutual acceptance of data Jarlath Hynes, BE-Brussels |
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| HALL 2 |
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| 13.2 Disease Models in vitro versus in vivo - Skin & ex vivo Tissues Chairs: Sarah Hedtrich, DE-Berlin & Roman Kolar, DE-Neubiberg |
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| 15:50-16:10 | Inflammatory skin disease models Sarah Hedtrich, DE-Berlin |
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| 16:10-16:30 | An inflammatory, filaggrin-deficient skin model demonstrates hallmarks of atopic dermatitis in vitro Stefan Hönzke, DE-Berlin |
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| 16:30-16:50 | Novel perspectives for in vitro models of human skin wounds Maike Windbergs, DE-Saarbrücken |
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| 16:50-17:05 | Fast and label-free tracking of cell behavior in non-animal models Karin Schütze, DE-Bernried |
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| 17:05-17:20 | Preclinical evaluation of CD30 as a novel molecular target in systemic mastocytosis Peter Valent, AT-Vienna |
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| HALL 3 |
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| 14.1 3Rs in Education and Academia - Academia Chairs: Monika Schäfer-Korting, DE-Berlin & Christa Thöne-Reineke, DE-Berlin |
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| 15:50-16:15 | BB3R – educating the next generation of scientists Monika Schäfer-Korting, DE-Berlin |
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| 16:15-16:35 | ReThink3R – innovation strategies for young scientists – Report of the first workshop Annemarie Lang, DE-Berlin |
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| 16:35-16:50 | CAAT Academy: From inception to launching Francois Busquet, BE-Ixelles |
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| 16:50-17:05 | A Course in Replacement Alternatives: To give the good example Candida Nastrucci, IT-Rome |
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| 17:05-17:20 | Improving transparency on quality and translatability of animal studies using new science driven approach Judith van Luijk, NL-Nijmegen |
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| Round table I 17:25-18:25 |
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| HALL 1 | ||
| 17:25-18:25 | "Building a career in the 3Rs area: successful biotech SMEs" Moderator: Rodger Curren, IIVS, US-Gaithersburg Participants: Samuel Constant, Epithelix & OncoTheis Sàrl, CH-Geneva Helena Kandarova, MatTek IVLSL, SK-Bratislava Jems Kelm, InSphero AG, CH-Schlieren Reyk Horland, TissUse GmbH, DE-Berlin Dmitry Sakharov, Bioclinicum Research Centre, Acad. Sciences, RU-Moscow |
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| 18:30 | Welcome reception (at the congress venue) | |
| Thursday, 25 August 2016 | ||
| Keynote lecture 09:00-09:30 | ||
| HALL 1 |
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| 09:00-09:30 | Real world medicine and real world patients: Something that animal testing can never approximate Michael Liebmann, US-Kennett Square |
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| Scientific sessions 09:35-11:05 |
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| HALL 1 | ||
| 4 Implementing Dir 2010/63/EU Chairs: Susanna Louhimies, BE-Brussels & Gilbert Schönfelder, DE-Berlin |
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| 09:35-09:55 | The role of the National Committees (NC) and Animal Welfare Bodies (AWB) under Directive 2010/63/EU Susanna Louhimies, BE-Brussels |
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| 09:55-10:10 | Towards a harmonized approach: Role of the German National Committee for the Protection of Animals Used for Scientific Purposes in the process of implementation of the Directive 2010/63/EU Justyna Chmielewska, DE-Berlin |
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| 10:10-10:25 | Role of the Swedish national committee in the harmonization of project authorization and evaluation Katarina Cvek, SE-Uppsala |
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| 10:25-10:40 | Establishing a culture of care by implementing AUGUST – a new and strong initiative at Aarhus University Birgitte Kousholt, DK-Aarhus N |
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| 10:40-10:55 | From the guideline to the bench – The role of science based policy advice in implementing EU Dir 63/2010 in Germany Henning Steinicke, DE-Halle |
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| 10:55-11:10 | Animal welfare requirements – significant room for improvement Irmela Ruhdel, DE-Neubiberg |
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| HALL 2 |
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| 5.1 Novel Approaches in Efficacy and Safety Testing – 3D models I Chairs: Jens Kelm, CH-Zurich & Joachim Wiest, DE-Munich |
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| 09:35-09:55 | A three-dimensional bioprinted liver equivalent for human-on-a-chip toxicity screenings Tobias Grix, DE-Berlin |
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| 09:55-10:15 | Studying liver toxicity and disease modelling using bioprinted 3D human liver tissue Christine Daly, UK-London |
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| 10:15-10:35 | Hepatic differentiation of hiPSC in co-culture with endothelial cells using different culture media Nora Freyer, DE-Berlin |
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| 10:35-10:50 | In vitro study of melatonin effect on HepG2 cells treated with IL-6 in newly developed liver on chip device Mi Jang, DE-Saarbruecken |
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| 10:50-11:05 | A modular cell sheet-based approach towards 3D tissue models Marie Weinhart, DE-Berlin |
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| HALL 3 |
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| 9.1 Predictive Toxicology - QSAR & Testing Strategies Chairs: Robert Landsiedel, DE-Ludwigshafen & Magdalini Sachana, FR-Paris |
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| 09:35-09:55 | OECD projects on Integrated Approaches to Testing and Assessment (IATA): a combination of mechanistic information and alternative methods to improve predictive toxicology Magdalini Sachana, FR-Paris |
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| 09:55-10:15 | EuroMix: using (Q)SARs, TTC, molecular docking simulation and read across as a first tier in mixture toxicity risk assessment Emiel Rorije, NL-Bilthoven |
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| 10:15-10:35 | A decision-making framework for the grouping and testing Josje Arts, NL-Arnhem |
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| 10:35-10:50 | A High Accuracy QSAR based on rabbit data to predict the human skin and eye irritation potential of individual constituents and mixtures Faizan Sahigara, FR-L’Isle D’Abeau |
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| 10:50-11:05 | Computational profiling as a proxy for drug hazard prediction in pharmaceutical research Friedemann Schmidt, DE-Frankfurt |
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| 11:15-13:15 | SEMINAR Classification and Reporting of Severity - date option II more details open to all participants of the EUSAAT 2016 Congress & open to external participants REGISTRATION REQUIRED - number of participants limited |
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| 11:05-11:30 | Coffee break and posters | |
| Scientific sessions 11:30-13:00 | ||
| HALL 1 |
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| 5.2 Novel Approaches in Efficacy and Safety Testing – 3D models II Chairs: Samuel Constant, CH-Plan-les-Ouates & Ellen Fritsche, DE-Duesseldorf |
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| 11:30-11:55 | OncoCilAir™: Organotypic human in vitro model for lung cancer research Samuel Constant, CH-Plan-les-Ouates |
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| 11:55-12:15 | Migrating to the 3rd dimension: the “Neurosphere Assay” to study migration disturbances during neurodevelopment Marta Barenys, DE-Duesseldorf |
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| 12:15-12:35 | The 'Neurosphere Assay' as a valuable part of a DNT testing strategy Ellen Fritsche, DE-Duesseldorf |
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| 12:35-12:55 | ATERA: advanced 3D human tissue models and exclusive testing services for cosmetic, consumer product and pharmaceutical industry Bart De Wever, LU-Esch-sur-Alzette |
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| HALL 2 |
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| 6.1 Stem Cells & Reproductive Toxicity (including mEST & hEST) - Stem Cells Chairs: Jürgen Hescheler, DE-Köln & Ole Pless, DE-Hamburg |
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| 11:30-11:50 | Cardiotoxicity gene and miRNA biomarkers induced by anticancer drugs Agapios Sachinidis, DE-Cologne |
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| 11:50-12:10 | Practical application of human iPS cells for chemical toxicity assessment Yasunari Kanda, JP-Tokyo |
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| 12:10-12:30 | A hiPSC-based test platform (DropTech®) for toxicity assessment of small molecule compounds in early stage drug discovery Ole Pless, DE-Hamburg |
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| 12:30-12:45 | Replacing animal testing by genotoxicity and carcinogenic cell transformation assessment using a tissue regenerating cell line from fish with GFP-labelled histones Petra Stahlschmidt-Allner, DE-Aarbergen |
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| 12:45-13:00 | A stem cell based metabolic activation system – Potential for replacing rat liver S9 fraction Cristiano F. Lerche, DE-Aarbergen |
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| HALL 3 |
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| 12 Efficacy of Drugs, Biologiocals & Vaccines Chairs: Tuula Heinonen, FI-Tampere & Katrin Schutte, BE-Brussels |
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| 11:30-11:50 | Towards global harmonisation of 3Rs in biologicals Katrin Schutte, BE-Brussels |
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| 11:50-12:10 | The “BINACLE” (binding and cleavage) assay allows in vitro determination of botulinum and tetanus neurotoxin activity Heike Behrensdorf-Nicol, DE-Langen |
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| 12:10-12:30 | G-protein based ELISA as a potency test for human rabies vaccines Martine Chabaud-Riou, FR-Marcy l'Etoile |
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| 12:30-12:45 | Development, optimization and validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model Epiderm Helena Kandarova, SK-Bratislava |
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| 12:45-13:00 | Animal Friendly Affinity Reagents (AFAs): making animal immunisation obsolete Alison Gray, FR-Morzine |
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| 13:00-14:00 | Business lunch (to be served at the congress venue) and posters |
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| Scientific sessions 14:00-15:30 |
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| HALL 1 |
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| 3 Ethical and Legal Issues Chairs: Roman Kolar, DE-Neubiberg & Katy Taylor, UK-London |
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| 14:00-14:15 | An ethical challenge to the normalisation of animal experimentation Kay Peggs, UK-Winchester |
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| 14:15-14:30 | A proposal for a catalogue of criteria to objectify the harm-benefit analysis of proposed projects including animal experiments Norbert Alzmann, DR-Tuebingen |
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| 14:30-14:45 | Applying the harm benefit assessment under the EU Directive – what does it mean in practice for animals? Katy Taylor, UK-London |
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| 14:45-15:00 | Biotechnological chimeras and experimentation: legislative lacunae legerdemain? Maureen O'Sullivan, IR-Galway |
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| 15:00-15:15 | Ethical aspects of the Crispr/Cas9 technology Henriette Bout, NL-Amsterdam |
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| 15:15-15:30 | Non-human primates in neuroscience research: Can it be ethical, if it isn’t scientifically necessary? Jarrod Bailey, UK-London |
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| HALL 2 |
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| 7.1 Refinement & Welfare: Culture of Care & Best Practice Approaches Chairs: Susanna Louhimies, BE-Brussels & Christa Thöne-Reineke, DE-Berlin |
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| 14:00-14:15 | Implementation of 3Rs for livestock animals in bioscientific research-rationale and objectives of the newly established expert working group – LaNiV Fabienne Ferrara, DE-Berlin |
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| 14:15-14:30 | Group housing of rats and rabbits - Thinking out of the box Kerstin Kleinschmidt-Dörr, DE-Darmstadt |
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| 14:30-14:45 | Refinement and reduction strategies in experimental stroke Christa Thöne-Reineke, DE-Berlin |
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| 14:45-15:00 | The drinking water as application route for pain management in bone-linked mice models – Combining a refinement and a basic research study Annemarie Lang, DE-Berlin |
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| 15:00-15:15 | Assessing laboratory mouse welfare using animal-based measures Elin Spangenberg, SE-Uppsala |
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| 15:15-15:30 | Reducing animal numbers by half: A hybrid preparation technique for the simultaneous investigation of histology and broncho-alveolar lavage parameters of the rat lung Martin Wiemann, DE-Muenster |
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| HALL 3 |
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| 13.1 Disease Models in vitro versus in vivo - Lung Infections Chairs: Samuel Constant, CH-Plan-les-Ouates & Claus Michael Lehr, DE-Saarbruecken |
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| 14:00-14:20 | Modeling severe infection in human lung tissue Katja Zscheppang, DE-Berlin |
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| 14:20-14:40 | The use of in vitro human airway epithelia for the development of novel antivirals Samuel Constant, CH-Plan-les-Ouates |
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| 14:40-15:00 | Novel cystic fibrosis in vitro model for safety and efficacy testing of new drug delivery systems against chronic Pseudomonas aeruginosa infections Jenny Juntke, DE-Saarbruecken |
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| 15:00-15:15 | Transient receptor potential (TRP) ion channels activation induce increased bronchoconstriction in passive sensitized vital human ex vivo precision-cut lung slices Susann Dehmel, DE-Hannover |
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| 15:15-15:30 | Modeling fungal infections within a three-dimensional perfused respiratory system Doris Wilflingseder, AT-Innsbruck |
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| 15:30-16:00 | Coffee break and posters | |
| Round table II 16:00-17:00 | ||
| HALL 1 | ||
| 16:00-17:00 | Implementing the concept of "Integrated Approaches to Testing and Assessment (IATA)" into international regulatory testing Moderator: Horst Spielmann, FU Berlin & EUSAAT, DE-Berlin Partipants: Stephanie Bopp, EURL ECVAM, IT-Ispra Rodger Curren, IIVS, US-Gaithersburg Derek Knight, ECHA, FI-Helsinki Robert Landsiedel, BASF, DE-Ludwigshafen Magdalini Sachana, OECD, FR-Paris Stefan Scholz, UFZ Helmholtz Centre, DE-Leipzig |
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| POSTER HALL | ||
| 17:00-19:00 | Poster session I with coffee - authors present Survey of the posters with presence of the authors |
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| HALL 2 | ||
| 19:15-20:30 | Annual General Assembly of EUSAAT (members only) | |
| Friday, 26 August 2016 |
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| Keynote lecture 09:00-09:30 | ||
| HALL1 | ||
| 09:00-09:30 | Combating infectious diseases, novel approaches and in vitro models Claus-Michael Lehr, DE-Saarbruecken |
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| Scientific sessions 09:35-11:05 |
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| HALL 1 | ||
| 5.3 Novel Approaches in Efficacy and Safety Testing – Multi-Organ-Chips I Chairs: Mark Rosowski, DE-Berlin & Dmitry Sakharov, RU-Moscow |
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| 09:35-09:55 | From organoid technology to Multi-Organ-Chip development for substance testing Mark Rosowski, DE-Berlin |
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| 09:55-10:15 | Increasing biological relevance in vitro: From single microtissues to micro-physiological systems Jens Kelm, CH-Zurich |
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| 10:15-10:35 | Creating organotypic oxygen tension in cell culture chambers using perfused flow and flexible chamber geometry Kelly Davidge, UK-Rotherham |
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| 10:35-10:50 | Online TEER measurements in Homunculus system for orally administered drugs testing Dmitry Sakharov, RU-Moscow |
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| 10:50-11:05 | Utilization of Hommunculus platform for evaluation of cytochrome P450 activity in "liver-on-a-chip" Andrey Poloznikov, RU-Moscow |
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| HALL 2 |
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| 8.2 Replacement of Animals in Research & Use of non-Animal Methods and Technologies - Serum Free Media Chairs: Stefanie Schindler, CH-Bern & Jan van der Valk, NL-Utrecht |
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| 09:35-10:00 | Serum-free media and serum alternatives Jan van der Valk, NL-Utrecht |
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| 10:00-10:20 | Towards the replacement of fetal bovine serum in cell culture applications Christopher Fassbender, UK-London |
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| 10:20-10:40 | A fetal bovine serum free cytotoxicity test following ISO 10993-5 Joachim Wiest, DE-Munich |
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| 10:40-11:00 | IONOSENSE POC: Integration of OECTs with live cells an a 12-well plate for in vitro diagnostics, Aimie Pavia, FR-Gardanne |
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| HALL 3 |
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| 11.1 Toxicology II - Skin Sensitization, Phototoxicity Chairs: Silvia Letasiova, SK-Bratislava & Klaus R. Schröder, AT-Linz |
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| 09:35-09:55 | Assessment of pre- and pro-haptens using non-animal test methods for skin sensitization Britta Wareing, DE-Ludwigshafen |
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| 09:55-10:15 | Extending the limits of the hCLAT assay – test of the sensitization potential of oxidative hair dyes Karsten Mewes, DE-Duesseldorf |
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| 10:15-10:35 | GARD – the future of sensitization testing using a genomics-based platform Anki Malmborg Hager, SE-Lund |
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| 10:35-10:50 | ITS for skin sensitization potential – 1 out of 2 or 2 out of 3? David Roberts, UK-Liverpool |
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| 10:50-11:05 | An improved reactive oxygen species assay for photosafety assessment of chemicals with limited aqueous solubility Yoshiki Seto, JP-Shizuoka |
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| 11:15-13:15 | SEMINAR Classification and Reporting of Severity - date option III more details open to all participants of the EUSAAT 2016 Congress & open to external participants REGISTRATION REQUIRED - number of participants limited |
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| 11:05-11:30 | Coffee break and posters | |
| Scientific sessions 11:30-13:00 | ||
| HALL 1 | ||
| 5.4 Novel Approaches in Efficacy and Safety Testing – Multi-Organ-Chips II Chairs: Reyk Horland, DE-Berlin & Helena Kandarova, SK-Bratislava |
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| 11:30-11:50 | Bringing a human heart & fat on a chip: microphysiological platforms as in vitro models of cardiac and adipose tissue Peter Loskill, DE-Stuttgart |
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| 11:50-12:10 | High-throughput microfluidic platform for culture of 3D-kidney tissue models Henriëtte Lanz, NL-Leiden |
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| 12:10-12:30 | Towards lung disease-on-chip models and personalized medicine application Colette Bichsel, CH-Bern |
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| 12:30-12:45 | Vascularization of Multi-Organ-Chips for tissue engineering and regenerative medicine Severin Mühleder, AT-Vienna |
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| 12:45-13:00 | Opportunities for Organ-on-a-Chip models in toxicological risk assessment Minne Heringa, NL-Bilthoven |
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| HALL 2 |
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| 7.2 Refinement & Welfare: Avoidance of Severe Suffering Chairs: Jana Keller, DE-Ludwigshafen & Katy Taylor, UK-London |
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| 11:30-11:50 | Focus on severe suffering: an update on RSPCA activity to end severe suffering Elliot Lilley, UK-Horsham |
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| 11:50-12:10 | Systematic reviews of animal studies equal the implementation of the 3Rs Merel Ritskes-Hoitinga, NL-Nijmegen |
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| 12:10-12:30 | A proposal for a table to support the classification of the overall severity of a proposed project including animal experiments Norbert Alzmann, DE-Tuebingen |
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| 12:30-12:45 | How to determine severity degrees for genetically altered rodents? Anne Zintsch, DE-Berlin |
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| 12:45-13:00 | Repeated isoflurane anesthesia in female mice–Assessing the severity of stress Katharina Hohlbaum, DE-Berlin |
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| HALL 3 |
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| 14.2 3Rs in Education and Academia - Education Chairs: Monika Schäfer-Korting, DE-Berlin & Christa Thöne-Reineke, DE-Berlin |
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| 11:30-11:50 | Teaching practical applications of animal welfare – a review over 10 years of the FELASA B-Course in Vienna Christiane Winding, AT-Vienna |
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| 11:50-12:10 | Education and Training Platform for Laboratory Animal Science (ETPLAS) Jan van der Valk, NL-Utrecht |
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| 12:10-12:30 | Development and establishment of an interdisciplinary international master program for laboratory animal science (MLAS): a contribution to the 3R principles Julia Steitz, DE-Aachen |
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| 12:30-12:45 | Advanced training course for veterinarians to qualify for Animal Welfare Officer Christa Thöne-Reineke, DE-Berlin |
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| 12:45-13:00 | Establishment of an education program that meets the needs of researchers and animals Jan Baumgart, DE-Mainz |
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| 13:00-14:00 | Business lunch (to be served at the congress venue) and posters |
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| Scientific sessions 14:00-15:30 | ||
| HALL 1 | ||
| 6.2 Stem Cells & Reproductive Toxicity (including mEST & hEST) - EST Chairs: Hajime Kojima, JP-Tokyo & Horst Spielmann, DE-Berlin |
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| 14:00-14:20 | Hand1-Luc Embryonic stem cell test (Hand1-Luc EST): A reporter gene assay using engineered mouse ES cells to evaluate embryotoxicity in vitro Florian Le Coz, JP-Osaka |
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| 14:20-14:40 | Automation-compatible EST assay Simon Ströbel, CH-Schlieren |
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| 14:40-15:00 | Prediction of relative developmental toxicity of antifungal compounds using the ES-D3 cell differentiation assay, combined with the BeWo transport model Hequn Li, UK-Sharnbrook |
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| 15:00-15:15 | Tests for the safety evaluation of a Chinese herbal medicine formula used in the treatment of atopic dermatitis Lucia Lu Li, CN-Hangzhou |
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| 15:15-15:30 | Good Cell Culture Practice for stem cells, stem-cell-derived models and organ-on-chip models Mardas Daneshian, DE-Konstanz |
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| HALL 2 |
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| 10.2 Toxicology I - Inhalation Toxicity Chairs: Rodger Curren, US-Gaithersburg & Julia Hoeng, CH-Neuchatel |
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| 14:00-14:15 | Evaluation of reconstituted human bronchial epithelium (MucilAir™) suitability for repeated dose testing Samuel Constant, CH-Plan-les-Ouates |
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| 14:15-14:30 | Metaplastic phenotype in human primary bronchiolar epithelial cells after repeated exposure to mainstream cigarette smoke at the air-liquid interface Michaela Aufderheide, DE-Hannover |
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| 14:30-14:45 | Establishment and charakterization of a lung/liver organ-on-a-chip model. Phase 1: Model charakterization David Bovard, CH-Neuchâtel |
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| 14:45-15:00 | Development of an in vitro inhalation toxicity test with potential regulatory applicability Anna Maione, US-Ashland MA |
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| 15:00-15:15 | Collaborative industry efforts to optimize and standardize in vitro methods suitable for tobacco regulatory science Erin Hill, US-Gaithersburg MD |
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| 15:15-15:30 | Novel Aerosol exposure devices for in-vitro toxicity testing at the air/liquid interface Tobias Krebs, DE-Waldkirch |
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| HALL 3 |
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| 13.3 Disease Models in vitro versus in vivo - Other Organs Chairs: Stefanie Schindler, CH-Bern & Sven Schnichels, DE-Tuebingen |
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| 14:00-14:20 | A human neuronal in vitro model for application in biomedical research and in pharmacological and toxicological investigations Stefan Schildknecht, DE-Konstanz |
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| 14:20-14:40 | 3D in vitro tissue models for infection studies with human pathogens Matthias Schweinlin, DE-Wuerzburg |
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| 14:40-15:00 | Retinal organotypic cultures as disease model for ophthalmic diseases – recently proposed models Sven Schnichels, DE-Tuebingen |
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| 15:00-15:15 | Analysis of a novel ex vivo organ model to simulate neurodegeneration in retina Stephanie Joachim, DE-Bochum |
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| 15:15-15:30 | Recent developments of disease and human in vitro models of the blood-brain barrier Winfried Neuhaus, AT-Vienna |
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| 15:30-16:00 | Coffee break and posters | |
| Scientific sessions 16:00-17:30 | ||
| HALL 1 |
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| 9.2 Predictive Toxicology - Read Across Chairs: Stephanie Bopp, IT-Ispra & Eric Stilgenbauer, FI-Helsinki |
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| 16:00-16:20 | The use of metabolomics in vivo as read across tool: a case study with phenoxy carboxylic acid herbicides Hennicke Kamp, DE-Ludwigshafen |
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| 16:20-16:40 | Supporting evidence in read across approaches: potential and limitations of new approaches and methodologies Eric Stilgenbauer, FI-Helsinki |
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| 16:40-17:00 | Improving confidence in read across: A case study for the oral repeated dose toxicity of β-Olefinic alcohols Mark Cronin, UK-Liverpool |
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| 17:00-17:15 | Simulating chemical kinetics and dynamics for the prediction of toxicity Alicia Paini, IT-Ispra |
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| 17:15-17:30 | New possibilities in mathematical toxicology Marko Raseta, UK-York |
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| HALL 2 |
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| 11.2 Toxicology II - Bio-barriers & Novel Testing Concepts Chairs: Claus Michael Lehr, DE-Saarbruecken & Erin Hill, US-Gaithersburg |
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| 16:00-16:20 | Cellular and non-cellular elements of the pulmonary air-blood barrier Claus-Michael Lehr, DE-Saarbruecken |
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| 16:20-16:40 | BioVaSc-TERM - a platform technology to engineer human barrier models Angela Rossi, DE-Wuerzburg |
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| 16:40-16:55 | The novel ToxTracker reporter system provides mechanistic insight into the genotoxic properties of compounds and materials Giel Hendriks, NL-Leiden |
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| 16:55-17:10 | Integration of conducting polymer devices with 3D human tissue models for in vitro toxicology testing Magali Ferro, FR-Gardanne |
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| 17:10-17:30 | If non-animal alternative tests are accepted by regulatory agencies, will industry use them? Rodger Curren, US-Gaithersburg MD |
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| HALL 3 |
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| 13.4 Disease Models in vitro versus in vivo - Using Data Bases & Information Tools Chairs: Brigitte Landesmann, IT-Ispra & Gilbert Schönfelder, DE-Berlin |
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| 16:00-16:25 | Defining the optimal animal model for translational research using gene set enrichment analysis Matthias Steinfath, DE-Berlin |
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| 16:25-16:50 | Modernizing law and policy to support innovation in preclinical pharmaceutical testing in the United States Elizabeth Baker, US-Washington |
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| 16:50-17:15 | From bedside to bench – adding human context to in vitro models Brigitte Landesmann, IT-Ispra |
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| POSTER HALL |
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| 17:30-19:00 | Poster session II with coffee - authors present Survey of the posters with presence of the authors |
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| 19:30 | Departure to the Social Evening | |
| 20:00 | Social Evening | |
| Saturday, 27 August 2016 | ||
| Keynote lecture 09:00-09:30 | ||
| HALL 2 |
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| 09:00-09:30 | The CRISPR/Cas9 sytstem: a game changer in the life sciences Malte Spielmann, DE-Berlin |
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| Scientific sessions 09:30-11:15 | ||
| HALL 2 |
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| 15.1 Young Scientists Lectures I Chairs: Lucia Lu Li, CN-Hangzhou & Horst Spielmann, DE-Berlin |
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| 09:30-09:45 | The use of human (non- 3D equivalent) skin assays (SkimuneTM) for the detection of adverse reactions, potency and efficacy Ana Ribeiro, UK-Newcastle |
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| 09:45-10:00 | An in vitro system to predict the pro-fibrotic potential of carbon nanotubes in the lung Hana Barosova, CH-Fribourg |
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| 10:00-10:15 | Use of human derived liver cell lines for the detection of genotoxic carcinogens Monika Waldherr, AT-Vienna |
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| 10:15-10:30 | Chronologically-aged fibroblasts significantly alter the morphology of reconstructed human skin Christian Hausmann, DE-Berlin |
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| 10:30-10:45 | Three dimensional cell culture model for toxicity and efficacy tests Karolin Fröhlich, DE-Jena |
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| 10:45-11:00 | Development of an innovative moving interface for an in vitro model of the epithelial intestinal barrier Joana Costa, IT-Massarosa |
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| 11:00-11:15 | Label-free monitoring of HepG2 spheroids – a platform for automated liver toxicity screening Sebastian Eggert, DE-Munich |
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| 11:15-11:40 | Coffee break and posters | |
| Scientific sessions 11:40-13:10 | ||
| HALL 2 |
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| 15.2 Young Scientists Lectures II Chairs: Mardas Daneshian, DE-Konstanz & Joachim Wiest, DE-Munich |
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| 11:40-11:55 | Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization Gerrit Müller, DE-Berlin |
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| 11:55-12:10 | A novel 3D in vitro model of the deep lung in both healthy and diseased state for screening of safety and efficacy of pulmonary (nano)medicines Remi Hendrix, DE-Saarbruecken |
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| 12:10-12:25 | Effects of anti-tumor drugs bevacizumab and cisplatin on cancer cell invaded human ex vivo lung tissue in an organotypic model as an alternative to animal experiments Sebastian Konzok, DE-Hannover |
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| 12:25-12:40 | Safety assessment in EU-substance law: An open door for alternative methods Lena Hehemann, CH-Fribourg |
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| 12:40-12:55 | Litter loss as a neglected welfare problem? Charlotte S. Leidinger, DE-Mainz |
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| 12:55-13:10 | Assessment of Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) for screening of anticancer activities of drugs Mahmoud Galal, EG-Cairo |
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| 13:10 | Closing Remarks and YSTA Lecture Award |
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| Saturday, 27 August 2016 | ||
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13:30-18:00 |
Day one - lectures open to all participants of the EUSAAT 2016 Congress, registration required |
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| Sunday, 28 August 2016 | ||
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09:00-13:00
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Day two - hands on open to all participants of the EUSAAT 2016 Congress, registration required |
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