Program per day
Abstractbook is online!
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lecture available as pdf for download |
| Thursday, 10 October 2019 |
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| YOU Event "Pre-registration meet-up for Young Scientists" 11:30-12:30 |
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For further details click here. (Registration requested) |
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| Opening & Keynote Lecture 13:00-13:45 | ||
| HALL 1 | ||
| 15 min | Welcome addresses Dagmar Jírová, Vice-President of EUSAAT, CZ-Prague & Horst Spielmann, Chair of the Scientific Committee, DE-Berlin |
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| 30 min | Keynote Lecture I Update on human stem cells - scientific, ethical and legal challenges Jürgen Hescheler, DE-Cologne |
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| Scientific sessions 13:55-15:25 | ||
| HALL 1 |
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| 1.1 3D Models & multi-organ-chips (MOC), human-organ-chips (HOC) - I Chairs: Horst Spielmann, DE-Berlin & Chiwan Chiang, NL-Leiden |
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| 20 min | Microphysiological flux balance platform unravels the dynamics of drug induced steatosis Avner Ehrlich, IL-Jerusalem awarded with the YSTA 2019 |
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| 20 min | 3D CNS model of iPSCs derived neuron and glia for high-throughput neurotoxicity screening in Mimetas’ OrganoPlate® Chiwan Chiang, NL-Leiden |
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| 20 min | An in vitro fracture hematoma model as a tool for preclinical drug testing Moritz Pfeiffenberger, DE-Berlin |
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| 15 min | The combination of 3D human cancer tissues and fluid-dynamic drug administration as winning strategy for in vitro drug efficacy testing Silvia Scaglione, IT-Genoa |
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| 15 min | Integrating Organ-on-a-Chip devices on a multimodal, microfluidic platform Eva Zittel, DE-Karlsruhe awarded with the YSTA 2019 |
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| HALL 2 |
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| 2.1 3R Centers in Europe & international - national and local centers - I Chairs: Chantra Eskes, CH-Bern & Adrian Smith, NO-Oslo |
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| 20 min | Norecopa: working to advance harmonisation and dissemination of best practice in animal research and testing Adrian Smith, NO-Oslo |
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| 20 min | Italian Centro3Rs commitment: 1 year after the opening of the activities Anna Maria Bassi, IT-Genoa |
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| 20 min | At crossroads between regulation, science and industrial application: the EPAA, a public-private initiative for the 3Rs Franz Lamplmair, BE-Brussels |
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| 15 min | A Society for Alternatives to Animal Experiments in India: An Update Mohammad Abdulkader Akbarsha, IN-Tiruchirappalli |
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| 15 min | Austria goes 3R - The RepRefRed Society Birgit Reininger-Gutmann, AT-Graz |
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| HALL 3 | ||
| 15 In vitro techniques for CNS toxicity and disease studies Chairs: Marius Hittinger, DE-Saarbrücken & Francesca Pistollato, IT-Ispra |
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| 20 min | An AOP-driven assessment of developmental neurotoxicity induced by chemical mixtures using human iPSC-derived neuronal/glial cultures Francesca Pistollato, IT-Ispra |
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| 20 min | In vitro neurotoxicity testing: functional neuron-specific endpoints Manuela Marcoli, IT-Genoa |
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| 20 min | The relevance of shear stress for in-vitro models of the human blood-brain barrier: a comparative study Anna Gerhartl, AT-Vienna |
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| 15 min | Modelling the human blood-brain-barrier microvasculature and nanocarrier transport on a microfluidic chip Marco Campisi, IT-Turin awarded with the YSTA 2019 |
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| 15:25-16:00 | Coffee break and posters | |
| Scientific sessions 16:00-17:30 | ||
| HALL 1 |
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| 9.1 Efficacy and safety testing of drugs, medical devices & biopharmaceutics - I Chairs: Dagmar Jirova, CZ-Prague & Shujun Cheng, CN-Shanghai |
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| 20 min | Implementing 3Rs by the pharmaceutical industry Kirsty Reid, BE-Brussels |
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| 20 min | Drivers for the pharmaceutical industry to adopt human stem-cell based models Ard Teisman, BE-Beerse |
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| 20 min | Replacement and Reduction examples from Novo Nordisk Thomas Bertelsen, DK-Maaloev |
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| 15 min | From a 3Rs intent to a company's strategy: perspective from the Industry Shahjahan Shaid, BE-Wavre |
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| 15 min | Stakeholder Collaboration to Advance Human-Relevant Nonclinical Methods for Drug Development in the United States Elizabeth Baker, US-Washington DC |
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| HALL 2 |
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| 19 Stem cell models and technology (hIPS, ES, mES, mIPS…) Chairs: Jürgen Hescheler, DE-Cologne & Ard Teisman, BE-Beerse |
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| 20 min | Human urine as a non-invasive source of kidney progenitor cells amenable for nephrotoxicity studies James Adjaye, DE-Düsseldorf |
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| 20 min | Advancing chemical safety assessments through integration of population-based in vitro models and computational methods Fabian Grimm, US-Annandale |
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| 20 min | Of mice, chicken and human induced pluripotent stem cells: studying midbrain dopaminergic neuron development and survival in the context of Parkinson’s Disease Nilima Prakash, DE-Hamm |
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| 15 min | Generation of hepatic organoids from human induced pluripotent stem cells Hyemin Kim, KR-Daejeon |
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| 15 min | Generation of functional macrophages from human induced pluripotent stem cells SeongYea Jo, KR-Daejeon |
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| HALL 3 | ||
| 5 An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment: Results of the in3 project Chairs: Paul Jennings, NL-Amsterdam & Maxime Culot, FR-Lens |
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| 20 min | An introduction to the in3 project Maxime Culot, FR-Lens Paul Jennings, NL-Amsterdam |
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| 20 min | In3 Project: a European initiative to evaluate toxicity of chemicals using iPSCs derived in vitro models: Focus on blood brain barrier models for neurotoxicity assessment Sara Wellens, FR-Lens |
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| 20 min | Study the effect of cyclosporin A on functionality of endothelial cells differentiated from iPS cells as in vitro toxicology model system Zahra Mazidi, AT-Vienna |
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| 15 min | Evaluation of human induced Pluripotent Stem Cell derived podocyte-like cells for toxicity testing Cormac Murphy, NL-Amsterdam |
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| 15 min | In vitro distribution kinetics and neurotoxicity of the cardiac drug amiodarone in the iPSC-derived human 3D model BrainSpheres Carolina Nunes, CH-Lausanne |
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| Round table I 17.40-19.00 |
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| HALL 1 | ||
| International impact of closing research animal facilities in Europe | ||
| Moderator Horst Spielmann, DE-Berlin Panelists Elizabeth Baker, US-Washington DC Julia Baines, UK-London Jürgen Hescheler, DE-Cologne Birgit Reininger-Gutmann, AT-Graz Christa Thöne-Reineke, DE-Berlin |
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| 19:15 | Welcome reception (at the congress venue) | |
| Friday, 11 October 2019 |
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| Keynote lecture 09:00-09:30 | ||
| HALL 1 |
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| 30 min | Implementing Directive 2010/63/EU - current status and next steps Susanna Louhimies, BE-Brussels |
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| Scientific sessions 09:40-11:10 |
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| HALL 1 | ||
| 12 Implementing EU Dir 63/2010 - update Chairs: Susanna Louhimies, BE-Brussels & Kirsty Reid, UK-Brussels |
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| 20 min | Project evaluation – importance of a coherent and consistent approach Susanna Louhimies, BE-Brussels |
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| 20 min | A user perspective towards improving the processes of project evaluation Kirsty Reid, BE-Brussels |
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| 20 min | Thematic review of animals used for scientific purposes: a mechanism for advancing replacement Christina Dodkin, UK-London |
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| 15 min | Initiative for better access and digitalisation to EU agencies safety data Francois Busquet, BE-Ixelles |
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| 15 min | Animalstudyregistry.org – a federal database for preregistration of animal research Justyna Chmielewska, DE-Berlin |
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| HALL 2 |
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| 7.1 Disease models using HUMAN cells, tissues and organs - I Chairs: Annemarie Lang, DE-Berlin & Doris Wilflingseder, AT-Innsbruck |
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| 20 min | Human-based T cell-skin models for graft-versus-host disease Maximiliane Wussmann, DE-Würzburg |
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| 20 min | Neuroprotection via an iNOS-inhibitor in a porcine retina organ culture model Stephanie C Joachim, DE-Bochum |
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| 20 min | Simulating an arthritic joint in vitro by combining multiple tissue components Alexandra Damerau, DE-Berlin |
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| 15 min | Development of an in vitro trabecular human bone model integrated in a perfusion system to simulate glucocorticoid-induced osteoporosis Karoline Diesing, DE-Berlin awarded with the YSTA 2019 |
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| 15 min | Adding DIMENSIONS and a COMPLEMENT-ary view on HIV-1 transmission Doris Wilflingseder, AT-Innsbruck |
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| HALL 3 |
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| 8 Ecotoxicology Chairs: Christopher Fassbender, DE-Stuttgart & Dipti Kapoor, IN-Delhi |
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| 20 min | Using PLHC-1 topminnow liver cells to characterize and predict the effect of plastic additives in fish Cinta Porte, ES-Barcelona |
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| 20 min | Reliable and representative in silico predictions of freshwater ecotoxicological hazardous concentrations Mélanie Douziech, NL-Nijmegen |
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| 20 min | From initiation to implementation: the RTgill-W1 cell line assay to predict fish acute toxicity of water samples and chemicals (ISO21115) Melanie Fischer, CH-Dübendorf |
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| 15 min | In vivo measurement of 7-methoxycoumarin-O-demethylase activity in zebrafish (Danio rerio) embryos Ann-Kathrin Lörracher, DE-Heidelberg |
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| 15 min | Gene expression upon immune challenge in a fish intestinal in vitro model Stephan Fischer, CH-Wallisellen |
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| 11:10-11:40 | Coffee break and posters | |
paid advertising
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| Scientific sessions 11:40-13:10 | ||
| HALL 1 |
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| 3.1 3Rs in education and academia - I Chairs: Chantra Eskes, CH-Bern & Candida Nastrucci, IT-Roma |
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| 20 min | Advancing the Three Rs education and training under a European Parliament Pilot Project Susanna Louhimies, BE-Brussels |
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| 20 min | 3Rs education in academia: experiences from the Swiss 3R competence centre Chantra Eskes, CH-Bern |
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| 20 min | Initiatives to promote the Three Rs in education and training Francesca Pistollato, IT-Ispra |
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| 15 min | 3R funding of research activities 2014-2019 in Denmark by the Danish 3R centre Lisbeth Knudsen, DK-Copenhagen |
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| HALL 2 |
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| 22.1 'Young Scientists' session - I Chairs: Kristina Wagner, DE-Neubiberg & Christian Zoschke, DE-Berlin |
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| 20 min | Session keynote Similarity of a career in the field of 3Rs and a Trans-Alpine Crossing Barbara Birk, DE-Ludwigshafen |
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| 20 min | P. aeruginosa infected co-culture of human cystic fibrosis bronchial epithelial cells as a preclinical test system for anti-infectives Justus Horstmann, DE-Saarbrücken awarded with the YSTA 2019 |
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| 20 min | Development of a test system for the investigation of the pulmonary mucus barrier Nina Grzeschik, DE-Saarbrücken |
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| 15 min | Differentiation of motor neurons for in vitro potency testing of Botulinum Neurotoxins Maren Schenke, DE-Hannover awarded with the YSTA 2019 |
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| 15 min | Engineering in vitro Lung Microbiota for Antimicrobial Treatment Daniela Pacheco, IT-Milan awarded with the YSTA 2019 |
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| HALL 3 |
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| 17 Replacement - advanced technologies Chairs: Elizabeth Baker, US-Washington DC & Jens Kurreck, DE-Berlin |
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| 20 min | Transitioning from mammalian animal testing to non-animal testing using the zebrafish (Brachydanio rerio) embryo as a whole organism model for regulatory decision-making in chemical risk assessments Cindy Woodland, CA-Ottawa |
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| 20 min | The importance of data quality and governance in the acceptance of Next Generation risk Assessment (NGRA) approaches Paul Russel, UK-Sharnbrook |
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| 20 min | Bioprinting of 3D organ models for virus and cancer research Jens Kurreck, DE-Berlin |
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| 15 min | Combining fluidic chips and 3D bioprinting - an approach to study tumor-microenvironment and angiogenesis in vitro Michael J. Ausserlechner, AT-Innsbruck |
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| 15 min | The Need for Non-Animal Recombinant Antitoxins Dipti Kapoor, IN-Dehli |
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| 13:10-14:00 | A) Business lunch (to be served at the congress venue) and posters |
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| B) Business lunch of the Austrian RepRefRed Society (for details & registration CLICK HERE) |
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| C) Business lunch of STEMCELLS Technologies (for details & registration CLICK HERE)  |
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| Poster session I 14:00-15:30 | ||
| POSTER HALL | ||
| Poster session with coffee Survey of the posters with presence of the authors |
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| Scientific sessions 15:30-17:00 |
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| HALL 1 |
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| 14 Initiative for implementing serum free culture media Chairs: Stina Oredson, SE-Lund & Jan van der Valk, NL-Utrecht |
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| 20 min | There is no ethical justification for the use of fetal bovine serum (FBS) Tilo Weber, DE-Neubiberg |
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| 20 min | Using platelet-rich human platelet lysate to substitute fetal calf serum for cultivation of mesenchymal stromal cells Moritz Pfeiffenberger, DE-Berlin |
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| 20 min | A totally defined animal product free cell culture medium for a 3D human tumour out-side the body Stina Oredsson, SE-Lund |
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| 15 min | Serum-free media contribute to better reproducibility in in vitro research Jan van der Valk, NL-Utrecht |
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| Important | Announcement 17:30-18:30 Björn Ekwall Memorial Award to Jan van der Valk, NL-Utrecht Introduction & Award Ceremony Stina Oredsson, SE-Lund following Björn Ekwall Memorial Award Lecture History of in vitro methods. Lessons learned? Jan van der Valk, NL-Utrecht followed by discussion |
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| HALL 2 |
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| 9.3 Efficacy and safety testing of drugs, medical devices & biopharmaceutics - III Chairs: Coenraad Hendriksen, NL-Bilthoven & Klaus R. Schröder, AT-Linz |
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| 20 min | Vaccine batch to vaccine batch comparison by consistency testing (VAC2VAC) Coenraad Hendriksen, NL-Bilthoven |
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| 20 min | Proteomic analysis of canine leptospira vaccines Thomas Schuenborg, DE-Langen |
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| 20 min | Development of an OECD Test Guideline for Androgen Receptor Transactivation Assays (ARTAs) Anne Milcamps, IT-Ispra |
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| 15 min | Improving Drug Toxicity Assays through the Oxygen-dependent Induction of Metabolic Zonation in Primary Rat Hepatocytes Benedikt Scheidecker, JP-Tokyo |
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| 15 min | 3R-alternatives to skin testing of bovine PPD tuberculins Elisabeth Balks, DE-Langen |
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| HALL 3 |
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| 16.1 Reduction & refinement - I Chairs: Jarrod Bailey, UK-London & Susanne Louhimies, BE-Brussels |
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| 20 min | Moving transparency to the next level – Non-technical project summaries under Directive 2010/63/EU Susanna Louhimies, BE-Brussels |
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| 20 min | Does the stress of laboratory life and experimentation on animals adversely affect research data? Jarrod Bailey, UK-London |
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| 20 min | Full implementation of refinement methods in practice through education and training Kathrin Herrmann, US-Baltimore |
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| 15 min | Towards an automated surveillance of well-being in mice using deep learning Katharina Hohlbaum, DE-Berlin awarded with the YSTA 2019 |
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| 15 min | Clicker training for small rodents – cognitive enrichment and beyond Nadine Baumgart, DE-Mainz |
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| 17:00-17:30 | Coffee break and posters | |
| Björn Ekwall Memorial Award & Award Lecture 17:30-18:30 | ||
| HALL 1 | ||
| 17:30-17:45 | Björn Ekwall Memorial Award to Jan van der Valk, NL-Utrecht Introduction & Award Ceremony Stina Oredsson, SE-Lund Björn Ekwall Memorial Foundation |
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| 17:45-18:15 18:15-18:30 |
Björn Ekwall Memorial Award Lecture History of in vitro methods. Lessons learned? Jan van der Valk, NL-Utrecht Discussion |
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| EUSAAT AGA 19:30-21:30 | ||
| HALL 2 | ||
| Annual General Assembly of EUSAAT (members only) |
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| YOU Event "Meet-the-Mentors" with wine & cheese 20:00 |
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| For further details click here. (Registration required) |
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| Saturday, 12 October 2019 |
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| Keynote lecture 09:00-09:30 | ||
| HALL1 | ||
| 30 min | Human Artificial Lymph Node Model (HuALN) for biopharmaceutical testing and disease modelling in vitro Christoph Giese, DE-Berlin |
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| Scientific sessions 09:40-11:10 |
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| HALL 1 | ||
| 1.2 3D Models & multi-organ-chips (MOC), human-organ-chips (HOC) - II Chairs: Klaus R. Schröder, AT-Linz & Jens Kurreck, DE-Berlin |
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| 20 min | Beating organs-on-chip as advanced tools in drug screening: engineered in vitro models of human organs and diseases Roberta Visone, IT-Milan awarded with the YSTA 2019 |
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| 20 min | Development of 3D skin model and 3D skin infection model, as advanced testing tools for the bio-evaluation of novel antimicrobial biomaterials for treating infected wounds Ayesha Idrees, IT-Turin awarded with the YSTA 2019 |
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| 20 min | Biology-Inspired Micro-physiological System Approaches to Solve the Prediction Dilemma of Substance Testing Horst Spielmann, DE-Berlin |
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| 15 min | Brief introduction of user-driven microphysiological system development in Japan Toshiyuki Kanamori, JP-Tsukuba |
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| 15 min | 3D in vitro scaffold based cell model of neuroblastoma for evaluating genotoxic and miRNA-targeted therapeutics Olga Piskareva, IR-Dublin |
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| HALL 2 |
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| 9.2 Efficacy and safety testing of drugs, medical devices & biopharmaceutics - II Chairs: Marius Hittinger, DE-Saarbrücken & Christoph Giese, DE-Berlin |
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| 20 min | Replacement of the potency assay for tick borne encephalitis virus vaccines Dieter Pullirsch, AT-Vienna |
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| 20 min | Development, pre-validation and validation of the EpiDerm in vitro skin irritation protocol for the medical devices extracts Silvia Letasiova, SK-Bratislava |
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| 20 min | Orally inhaled drug products – The strengths and weaknesses of simplified in vitro methods Marius Hittinger, DE-Saarbrücken |
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| 15 min | Development of recombinant antibodies to replace animal sera Maximilian Ruschig, DE-Braunschweig |
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| 15 min | Current status of the implementation of new methods in cardiotoxicity safety testing Christiane Hohensee, DE-Erkrath |
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| HALL 3 |
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| 2.2 3R Centers in Europe & international - national and local centers - II Chairs: Helena Kandarova, SK-Bratislava & Dagmar Jirova, CZ-Prague |
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| 20 min | Charité 3R – the 3R Center of Charité Universitätsmedizin Berlin Annemarie Lang, DE-Berlin |
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| 20 min | Slovak National Platform for Three Rs (SNP 3Rs) in Science, Education, Research and Development Helena Kandarova, SK-Bratislava |
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| 20 min | 3Rs Center at the National Institute of Public Health in the Czech Republic Dagmar Jírová, CZ-Prague |
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| 15 min | Animal experiments or humane alternatives: awareness raising campaign in Belarus Tatsiana Hlinkina, BY-Minsk |
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| 15 min | Asian Consortium for Three Rs Hajime Kojima, JP-Tokyo |
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| 11:10-11:40 | Coffee break and posters | |
paid advertising
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| Scientific sessions 11:40-13:10 |
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| HALL 1 | ||
| 16.2 Reduction & refinement - II Chairs: Christa Thöne-Reineke, DE-Berlin & Stefanie Schindler, DE-Konstanz |
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| 20 min | Ethical justification of animal experiments in Germany Christa Thöne-Reineke, DE-Berlin |
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| 20 min | The Animal Protection Quality Certificate. A tool to assess refinement methods in animal experiments Roberto Plasenzotti, AT-Vienna |
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| 20 min | Developing a new simulator of the rat for laboratory animal training courses using 3D printing Giuliano Mario Corte, DE-Berlin |
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| 15 min | Viva3R! Stefanie Schindler, DE-Konstanz |
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| 15 min | Refinement in laboratory animal science education – An inquiry concerning the use of rat and mouse simulators among LAS instructors Melanie Humpenöder, DE-Berlin |
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| HALL 2 |
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| 6 Biological barriers Chairs: Winfried Neuhaus, AT-Vienna & Marius Hittinger, DE-Saarbrücken |
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| 20 min | Apparent permeability coefficients of ciprofloxacin in human lung epithelial cells appropriately predict bioavailability after inhalation exposure Nico Sonnenschein, DE-Hannover |
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| 20 min | ALT4EI: Assessment of eye irritating potential of 59 chemicals using EpiOcular™ time-to-toxicity (EpiOcular ET-50) neat and dilution protocols Silvia Letasiova, SK-Bratislava |
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| 20 min | The Blood-Saliva Barrier: An optimized in vitro model of the oral epithelium and its relevance for biomarker research Grace Lin, AT-Vienna |
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| 15 min | Modeling of drug toxicity and permeability using the reconstructed 3D model of small intestine Jan Markus, SK-Bratislava |
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| 15 min | Using ex vivo human skin for the assessment of drug transport across the skin barrier with label-free Raman microscopy Nathalie Jung, DE-Frankfurt/Main awarded with the YSTA 2019 |
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| HALL 3 |
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| 10 Ethical & legal issues Chairs: Lindsay Marshall, US-Washington DC & Kristina Wagner, DE-Neubiberg |
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| 20 min | Normalizing the unthinkable: The report of the Oxford Centre for Animal Ethics Clair Linzey, UK-Oxford |
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| 20 min | Modernising research and regulatory policies to advance human health Julia Baines, UK-London |
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| 20 min | The impact of closure of specialised mouse research facilities Lindsay Marshall, US-Washington DC |
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| 15 min | Towards veterinary ethics Kerstin Weich, AT-Vienna |
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| 15 min | Why are alternative methods (not) chosen? Presentation of a project on the investigation of value judgments for or against alternatives in animal testing in basic research Ines Pietschmann, DE-Hannover |
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| 13:10-14:00 | Business lunch (to be served at the congress venue) and posters |
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| Poster session II 14:00-15:30 | ||
| POSTER HALL | ||
| Poster session with coffee Survey of the posters with presence of the authors |
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| Scientific sessions 15:30-17:00 | ||
| HALL 1 |
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| 13 In silico models Chairs: Annemarie Lang, DE-Berlin & Jakub Kostal, US-Washington DC (This session is sponsored by the Lush Prize.) |
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| 20 min | The many cards up ‘computational sleeves’: reshaping in silico tools used in drug discovery to design safer and functional chemicals Jakub Kostal, US-Washington DC |
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| 20 min | Combining in vitro and in silico modelling to simulate cartilage degradation during osteoarthritis Annemarie Lang, DE-Berlin |
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| 20 min | Using big data for developing QSAR models to predict interaction of chemicals with neuronal proteins Yaroslav Chushak, US-Dayton |
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| 15 min | Using the OECD QSAR toolbox as an in silico modelling method for computational aquatic toxicology of endocrine disruptors Dahye Kim, DE-Saarbrücken |
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| 15 min | What can (Q)SAR modelling can tell us about fish toxicity? Pascal Bicherel, FR-L’Isle D’Abeau |
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| HALL 2 |
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| 3.2 3Rs in education and academia - II Chairs: Györgyi Szabo, HU-Budapest & Thöne-Reineke, DE-Berlin |
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| 20 min | Education towards non-animal approaches in basic and applied biomedical research Kathrin Herrmann, US-Baltimore |
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| 20 min | Refinement in education Györgyi Szabó, HU-Budapest |
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| 20 min | Innovations in veterinary education and training and the feasibility of full replacement Nick Jukes, UK-Leicester |
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| 15 min | Time to rethink the 3Rs after 60 years. Time for just 1R: Replacement and non-animal research Candida Nastrucci, IT-Rome |
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| HALL 3 |
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| 4 Advanced safety testing of cosmetics & consumer products and alternatives to animal testing in food safety, nutrition and efficacy Chairs: Rebecca Ram, UK-Kingsbridge & Kristina Wagner, DE-Neubiberg |
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| 20 min | Cosmetic perfumes and their potential of endocrine disruption, sensitization and genotoxicity Marketa Dvorakova, CZ-Prague |
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| 20 min | Safety testing of adult novelties using methods in vitro Lada Bělastová, CZ-Prague awarded with the YSTA 2019 |
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| 20 min | Collaboration for non-animal cosmetic safety assessment globally by 2023 Paul Russell, UK-Sharnbrook |
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| 15 min | Gluconeogenic processes in a bovine liver cell line offered short chain fatty acids Anna-Maria Sittel, DE-Leipzig |
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| 15 min | Demonstration of different intestinal absorption mechanisms of lactulose and mannitol by using 3D tissue inserts within fluidic multi-chamber devices Silvia Scaglione, IT-Genoa |
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| Round table II 17:10-19:00 | ||
| HALL 1 | ||
| Establishing an International 3Rs Centers Network | ||
| Moderator Winfried Neuhaus, AT-Vienna Panelists Dagmar Jírová, CZ-Prague Helena Kandarova, SK-Bratislava Hajime Kojima, JP-Tokyo Annemarie Lang, DE-Berlin Adrian Smith, NO-Oslo Györgyi Szabo, HU-Budapest |
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| 19.15 | Departure to the Social Evening | |
| 20.00 | Social Evening | |
| Sunday, 13 October 2019 |
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| Keynote lecture 09:00-09:30 | ||
| HALL 1 |
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| 30 min | Challenging FDA’s requirement for long term studies in dogs for the safety assessment of drugs and pharmaceuticals Mihael H. Polymeropoulos, US-Washington DC |
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| Scientific sessions 09:40-11:10 | ||
| HALL 1 |
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| 18 Specific endpoints of toxicity Chairs: Horst Spielmann, DE-Berlin & Hajime Kojima, JP-Kawasaki |
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| 20 min | Recent efforts to elucidate the scientific validity of animal-based drug tests by the pharmaceutical industry, pro-testing lobby groups, and animal welfare organisations Jarrod Bailey, UK-London |
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| 20 min | Interpreting irregular LLNA data for evaluation of non-animal methods for skin sensitization David Roberts, UK-Liverpool |
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| 20 min | OECD DRP on in vitro assays in reproductive toxicology Hajime Kojima, JP-Kawasaki |
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| 15 min | Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines Lucia Li, CN-Hangzhou & Horst Spielmann, DE-Berlin |
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| HALL 2 |
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| 7.2 Disease models using HUMAN cells, tissues and organs - II Chairs: Ashwani Sharma, FR-Saint-Grégoire & Beate Rinner, AT-Graz (to be confirmed) |
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| 20 min | Cultivation of primary melanoma cells with human platelet lysate or bovine serum show different phenotypic and genotypic characteristics Beate Rinner, AT-Graz |
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| 20 min | In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds Irene Carmagnola, IT-Turin |
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| 20 min | HepaRG™: an integrated model for studying bile canalicular functions and dysfunctions for studying Cholestasis Toxicity Ashwani Sharma, FR-Saint-Grégoire |
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| 15 min | Sensitive and automated assessment of DNA strand break by AUREA gTOXXs in HepaRGTM Dirk Dressler, DE-Esslingen |
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| 15 min | Transcriptomic, metabolic and toxicological comparison of the human liver derived HepaRG with the human kidney derived RPTEC/TERT1 cells Paul Jennings, NL-Amsterdam |
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| HALL 3 |
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| 21 Animal experimentation: working towards a paradigm change (inspired by the book with the same title, eds: K. Herrmann and K. Jayne) Chairs: Kathrin Herrnmann, US-Baltimore & Dipti Kapoor, IN-Delhi |
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| 20 min | Refinement on the way towards Replacement: Are we doing what we can? Kathrin Herrmann, US-Baltimore |
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| 20 min | Animal research for Alzheimer's Disease: failures of science and ethics Francesca Pistollato, IT-Ispra |
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| 20 min | CRISPR-mediated gene editing: scientific and ethical issues Jarrod Bailey, UK-London |
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| 15 min | Replacing animal tests to improve safety for humans Jan Turner, UK-Kingsbridge |
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| 15 min | How can the final goal of completely replacing animal procedures successfully be achieved? Carolin Spicher, DE-Munich |
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| 11:10-11:40 | Coffee break and posters | |
| Scientific sessions 11:40-13:10 | ||
| HALL 1 | ||
| 11 Free communications Chairs: Elizabeth Baker, US-Washington DC & Gyögyi Szabo, HU-Budapest |
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| 20 min | Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? A systematic analysis of opinion papers Pandora Pound, UK-Kingsbridge |
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| 20 min | California Cruelty-Free Cosmetics Act establishes first North American law banning the sale of animal tested cosmetics and ingredients Elizabeth Baker, US-Washington DC |
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| 20 min | When the co-culture does not do what it is supposed to do – a step “back” to ex vivo models Sabrina Schnur, DE-Saarbrücken |
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| 15 min | Regulation of Endocrine Disruptors: REACH may change, but will the science evolve? Emma Grange, UK-London |
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| 15 min | Repeating past mistakes: The banality and futility of nowadays cigarette smoke-related animal experimentation Dilyana Filipova, DE-Cologne |
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| HALL 2 | ||
| 20 How to account for uncertainties of reference methods & data? Chairs: Roman Liska, IT-Ispra & Martin Paparella, AT-Innsbruck |
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| 20 min | On the uncertainty of toxicological methods: Quantifying the borderline range of prediction models and implications for decision-making Robert Landsiedel, DE-Ludwigshafen |
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| 20 min | Fish acute toxicity: Which data do we need and where do we get these from? Thomas Braunbeck, DE-Heidelberg |
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| 20 min | Animal free development, testing, parameterisation and calibration of human PBPK models for two plasticisers Kevin McNally, UK-Buxton |
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| 15 min | Assessment of uncertainties – ECVAM experience from recent in-vitro validation studies Roman Liska, IT-Ispra |
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| 15 min | Accounting of uncertainties for complex endpoints: What do we want to know? Martin Paparella, AT-Innsbruck |
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| HALL 3 | ||
| 22.2 'Young Scientists' session - II Chairs: Christopher Fassbender, DE-Stuttgart & Annemarie Lang, DE-Berlin |
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| 20 min | A novel model for mechanical assessment of biomaterials Constantinos Voniatis, HU-Budapest awarded with the YSTA 2019 |
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| 20 min | A reconstructed human skin model containing macrophages to set up a delayed wound healing model of cutaneous leishmaniasis Priscila Schilrreff, AR-Buenos Aires awarded with the YSTA 2019 |
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| 20 min | An innovative in vitro physiological relevant model as a tool to test therapeutic strategies for glaucoma Stefania Vernazza, IT-Genoa |
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| 15 min | Development of a human pancreatic cell line with optogenetically controllable receptor for high content screening Anna Stierschneider, AT-Krems |
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| 15 min | Design of experimental animal surgical models: Creation of a mouse uterus 3D-model for learning the in-utero electroporation Maximilian Nuber, DE-Mainz |
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| Closing Remarks & "Young Scientists Travel Awards Ceremony" 13:15-13:45 | ||
| HALL 1 | ||
| 15 min | Invitation lecture to the 11th World Congress on Alternatives to Animal Use in the Life Sciences Jos Kleinjans, NL-Maastricht |
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| 15 min | YSTA Award Ceremony & Closing Remarks Winfried Neuhaus, President of EUSAAT, AT-Vienna & Horst Spielmann, Chair of the Scientific Committee, DE-Berlin |
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